Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation
of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis …

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive
oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

Bone metastases are a frequent complication of many cancers that result in severe disease
burden and pain 1 , 2 , 3 . Since the late nineteenth century, it has been thought that the …

… We thank members of the Stockwell and Dixon labs for comments on the manuscript. SJD
(1R01GM122923) and BRS (R35CA209896, P01CA087497) are supported by the National …

Ferroptosis is a regulated form of necrotic cell death that is caused by the accumulation of
oxidized phospholipids, leading to membrane damage and cell lysis 1 , 2 . Although other …

Dietary lipids impact development, homeostasis, and disease, but links between specific
dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of …

Cell death can be executed by regulated apoptotic and nonapoptotic pathways, including the
iron-dependent process of ferroptosis. Small molecules are essential tools for studying the …

Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells
or be activated in specific pathological states. The oncogenic RAS-selective lethal small …

Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation
of lipids 1 , 2 . The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (…