The receptors for the second messenger inositol 1,4,5-trisphosphate (IP 3 ) constitute a
family of Ca 2+ channels responsible for the mobilization of intracellular Ca 2+ stores. Three …

Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) serve to discharge Ca 2+ from ER stores in
response to agonist stimulation. The present review summarizes the role of these receptors in …

Receptor occupation by a variety of Ca2+-mobilizing hormones, such as alpha 1-adrenergic
agents, vasopressin and angiotensin II, causes a rapid phosphodiesterase-mediated …

Background Glioblastoma (GBM) is the most common primary malignant brain cancer, and
is currently incurable. Chimeric antigen receptor (CAR) T cells have shown promise in GBM …

Recurrent medulloblastoma and ependymoma are universally lethal, with no approved
targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent …

Oxidant stress influences many cellular processes, including cell growth, differentiation, and
cell death. A well-recognized link between these processes and oxidant stress is via …

We report the stoichiometric phosphorylation of an inositol 1,4,5-trisphosphate receptor-binding
protein from rat brain by the cAMP-dependent protein kinase but not by protein kinase C …

Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals
between the IP 3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central …

Ca 2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial
bioenergetics and cell function. The MCU complex is the major pathway by which these signals …

Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrate remarkable efficacy in
treating B-lineage acute lymphoblastic leukemia (BL-ALL), yet up to 39% of treated patients …