… Although the BCL-2 gene was first discovered because of its involvement in t(14;lS)
translocations found frequently in non-Hodgkin’s lymphomas, high levels and aberrant patterns of …

The incretin hormone GLP1 promotes islet-cell survival via the second messenger cAMP.
Here we show that mice deficient in the activity of CREB, caused by expression of a dominant-…

Dysregulation of normal programmed cell death mechanisms plays an important role in the
pathogenesis and progression of breast cancer, as well as in responses of tumors to …

… for 15 s, endogenous peroxidase activity was quenched by incubation for 30-45 min in 2%
HzO2 in methanol. After sequentially washing in absolute ethanol (20 s), 70% ethanol (20 s), …

The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown
mechanism. Here we demonstrate that a temperature-sensitive p53 induces temperature-…

Background Loss of myocytes is an important mechanism in the development of cardiac
failure of either ischemic or nonischemic origin. However, whether programmed cell death (…

… For CTL experiments, Jurkat cells were labeled with S~Cr and cultured for 4 hr with CTLs at
… to JCR We thank S. Huang for helpful discussions, J. Smith for the ~-gal virus, S. Takahashi …

… The variability in IAP protein levels seen here among the NCI’s 60 human tumor cell lines
suggests that further correlative studies of IAP expression with clinical outcome and with other …

We investigated the mechanism of lysosome-mediated cell death using purified recombinant
pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line …

B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily
by defective programmed cell death (PCD), as opposed to increased cell proliferation. …