… S. MoRRIS KuPCHAN … I t is noteworthy that S. dulcamara L. has been used to treat
cancers, tumors, and warts from the time of Galen (c. …

The presence of an a-methylene-7-lactone is essential for significant cytotoxic activity among
the sesquiterpene lactones. The biological activity is enhanced by the presence of certain …

Maytansine, at 6 × 10 -8 M, irreversibly inhibits cell division in eggs of sea urchins and clams.
It causes the disappearance of a mitotic apparatus or prevents one from forming if added at …

Bruceantin and bruceantarin, new anti-leukemic simaroubolides from Brucea antidysenterica,
a plant used in Ethiopia inthe treatment of cancer, are shown to have structures 1 and 2, …

Thiols are the most reactive nucleophilic reagents among the biological models investigated.
They undergo "Michael-type" addition to the polyfunctional sesquiterpene lactones. The …

A chloroform extract of Vernonia amygdalina Del. was found to show significant inhibitory
activity in vitro against cells derived from human carcinoma of the nasopharynx (KB) carried in …

Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which
have been used widely in folk medicine for treating cancers, showed antileukemic activity …

(4) Wood of stems and stem bark were collected in Ethiopia in March 1971. We thank Dr.
Robert E. Perdue, Jr., US Department of Agriculture, Beltsville, Md., for supplying the plant …

The isolation and structural elucidation of the new potent antileukemic principles,
bruceantin (1) andbrucean-tinol (3), and the new companion quassinoids, bruceantarin (2), …

L4Cu LgCu-L'-CuLj m 3r does not take part in binding CO but may stabilize the protein, whereas
in structure V the second copper may influence CO binding through a bridging ligand or …