Heilendes Gift: Peptide aus dem Gift der Kegelschnecke sind potenzielle Therapeutika zur
Behandlung von neuropathischem Schmerz. Ein Nachteil dieser Peptide ist ihre kurze …

Conotoxins (CTXs), with their exquisite specificity and potency, have recently created much
excitement as drug leads. However, like most peptides, their beneficial activities may …

Disulfide bonds are important structural motifs that play an essential role in maintaining the
conformational stability of many bioactive peptides. Of particular importance are the …

The α-conotoxin Vc1.1 is a small disulfide-bonded peptide currently in development as a
treatment for neuropathic pain. This study describes the synthesis, determination of the …

α-Conotoxins are tightly folded miniproteins that antagonize nicotinic acetylcholine
receptors (nAChR) with high specificity for diverse subtypes. Here we report the use of …

Glutamate is the main excitatory neurotransmitter of the CNS. Tissue‐type plasminogen
activator (tPA) is recognized as a modulator of glutamatergic neurotransmission. This attribute is …

The synthetic α-conotoxin Vc1.1 is a small disulfide bonded peptide currently in development
as a treatment for neuropathic pain. Unlike Vc1.1, the native post-translationally modified …

Vc1.1 is a disulfide-rich peptide inhibitor of nicotinic acetylcholine receptors that has stimulated
considerable interest in these receptors as potential therapeutic targets for the treatment …

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the
folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see …

The venoms of predatory marine snails (Conus spp.) contain diverse mixtures of peptide
toxins with high potency and selectivity for a variety of voltage-gated and ligand-gated ion …