Objective Phencyclidine (PCP," angel dust") induces a psychotomimetic state that closely
resembles schizophrenia. As opposed to amphetamine-induced psychosis, PCP-induced …

Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic
acid (NMDA) receptors. In a double-blind, placebo-controlled fashion, 14 …

Over the last 20 years, glutamatergic models of schizophrenia have become increasingly
accepted as etiopathological models of schizophrenia, based on the observation that …

[ 3 H]Gamma-aminobutyric acid (GABA) binds to synaptic membrane fractions of rat brain in
a selective fashion representing an interaction with postsynaptic GABA receptors. Inhibition …

Glycine is an agonist at brain N-methyl-d-aspartate receptors and crosses the blood-brain
barrier following high-dose oral administration. In a previous study, significant improvements …

[3H]Phencyclidine (PCP) bound specifically and with high affinity (Kd = 0.15 microM at pH
7.4) to a single saturable class of binding sites in rat brain membrane preparations. Specific …

H istorically, receptors for a given substance have been classified using rather stringent
criteria, such as the order of potency of a large group of agonists, the relative potency of …

Introduction Activation of metabotropic glutamate (mGluR2/3) receptors has been proposed
as an alternative mechanism to dopaminergic-based antipsychotics to correct glutamatergic …

Chronic administration of the long-lived narcotic antagonist naltrexone resulted in a marked
increase in brain opiate receptors. Similar changes in receptor density were observed for …

The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine
were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat …