We have replaced the C-terminal portion of the third intracellular loop of the beta 2-adrenergic
receptor (residues 266-272) with the homologous region of the alpha 1B-adrenergic …

Adrenoceptors are prototypic members of the superfamily of seven transmembrane domain,
G protein-coupled receptors. Study of the properties of several mutationally activated …

Mutations in an intracellular region of the alpha 1B-adrenergic receptor constitutively activate
the receptor, resulting in G protein coupling in the absence of agonist, as evidenced by …

The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with
oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified …

Site‐directed mutagenesis and molecular dynamics simulations of the alpha 1B‐adrenergic
receptor (AR) were combined to explore the potential molecular changes correlated with the …

A novel alpha 1-adrenergic receptor subtype has been cloned from a bovine brain cDNA
library. The deduced amino acid sequence is that of a 466-residue polypeptide. The structure is …

To investigate the functional role of different α 1 -adrenergic receptor (α 1 -AR) subtypes in
vivo, we have applied a gene targeting approach to create a mouse model lacking the α 1b -…

Drugs of abuse, such as psychostimulants and opiates, are generally considered as exerting
their locomotor and rewarding effects through an increased dopaminergic transmission in …

The alpha 1B-adrenergic receptor (alpha 1B-ADR) is a member of the G-protein-coupled
family of transmembrane receptors. When transfected into Rat-1 and NIH 3T3 fibroblasts, this …

Pharmacological and molecular cloning studies have demonstrated heterogeneity of alpha
1-adrenergic receptors. We have now cloned two alpha 1-adrenergic receptors from a rat …