Fluorescence anisotropy assay was implemented for characterization of ligand binding
dynamics to melanocortin 4 (MC 4 ) receptors. This approach enables on-line monitoring of …

We present here the implementation of budded baculoviruses that display G protein-coupled
receptors on their surfaces for the investigation of ligand–receptor interactions using …

Despite the availability of numerous conceptually different approaches for the characterization
of ligand-receptor interactions, there remains a great requirement for complementary …

The melanocortin 4 receptor (MC 4 R) binding of the peptide analogue of melanocyte
stimulating hormone, [ 125 I]NDP-MSH, and the low molecular weight radionucleid 1-(d-1,2,3,4-…

This study evaluates the binding the melanocyte stimulating hormone peptide analogue [
125 I]NDP-MSH to melanocortin receptors MC 1 , MC 3 , MC 4 and MC 5 in insect cell …

Proteochemometrics was applied in the analysis of the binding of organic compounds to
wild-type and chimeric melanocortin receptors. Thirteen chimeric melanocortin receptors were …

Studying mechanisms of receptor–ligand interactions has remained challenging due to several
limitations of different measurement methods. Here we present a total internal reflection …

The melanocortin receptors exist in five subtypes, MC 1–5 R. These receptors participate in
important regulations of the immune system, central behavior, and endocrine and exocrine …

Melanocortin‐4 receptors (MC 4 R) are unique among G‐protein‐coupled receptors (GPCRs)
as they have endogenous ligands that can exhibit inverse agonistic properties in the case …

Ligand binding dynamics and the concept of drug-target residence time are essential factors
in the development of novel drugs. Conventional ligand binding assays, which usually …