β-Thalassemia/HbE disease is clinically variable. In searching for genetic factors modifying
the disease severity, patients were selected based on their disease severities, and a genome…

Pro-inflammatory mediators produced during inflammatory response have been demonstrated
to initiate and aggravate pathological development of several chronic diseases. Plant …

β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it
is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin …

Repair of β-globin pre-mRNA rendered defective by a thalassemia-causing splicing mutation,
IVS2–654, in intron 2 of the human β-globin gene was accomplished in vivo in a mouse …

Iron overload induces intestinal-permeability defect (gut leakage), and gut translocation of
organismal molecules might enhance systemic inflammation and sepsis severity in patients …

Malaria is a common parasitic disease in tropical countries, causing one to two million deaths
every year. To establish the new biomarker, we analyzed plasma miRNAs obtained from …

Basic diagnosis of hemoglobinopathies can be performed by analysis of erythrocyte indices
as well as by the separation and quantification of the common hemoglobin (Hb) fractions Hb …

Correct human β-globin mRNA has been restored in erythroid cells from transgenic mice
carrying the human gene with β-globin IVS2–654 splice mutation and from thalassemia …

Introduction Systemic inflammation induced by gut translocation of lipopolysaccharide (LPS),
a major component of Gram-negative bacteria, in thalassemia with iron-overload worsens …

Iron overload in patients with β-thalassemia can cause oxidative organ dysfunction. Iron
chelation along with antioxidant supplementation can ameliorate such complications and …