The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide
(2R,3R)-…

Neuronal nicotinic acetylcholine receptors are differentially sensitive to blockade by the
competitive antagonist dihydro‐β‐erythroidine. Both α and β subunits participate in determining …

We constructed a series of chimeric and mutant neuronal nicotinic acetylcholine receptor β
subunits to map amino acid residues that determine sensitivity to competitive antagonists. …

It has been hypothesized that alcohol addiction is mediated, at least in part, by specific γ-aminobutyric
acid A (GABA A) receptors within the ventral pallidum (VP). Among the potential …

We investigated the potential role of the α 1 -containing GABA A receptor in regulating the
reinforcing properties of alcohol. To accomplish this, we developed 3-propoxy-β-carboline …

The competitive antagonist α-conotoxin-MII (α-CTx-MII) is highly selective for the α3β2
neuronal nicotinic receptor. Other receptor subunit combinations (α2β2, α4β2, α3β4) are >200-…

GABA receptors within the mesolimbic circuitry have been proposed to play a role in regulating
alcohol-seeking behaviors in the alcohol-preferring (P) rat. However, the precise GABA A …

The primary purpose of the present series of experiments was to characterize the in vitro
and in vivo pharmacology profile of 2-(4-methoxy-phenyl)-N-(4-methyl-benzyl)-N-(1-methyl-…

Background: Previous research has implicated the α5‐containing GABA A receptors of the
hippocampus in the reinforcing properties of alcohol. In the present study, a selective GABA A …

The α and β subunits of heteromeric neuronal nicotinic acetylcholine receptors (nAChRs)
are thought to contribute “principal” and “complementary” components to the agonist binding …