Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants
implicated in numerous disease processes 1 , 2 , 3 , as demonstrated by its capacity of …

System L is a major nutrient transport system responsible for the transport of large neutral
amino acids including several essential amino acids. We previously identified a transporter (L-…

A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a
human kidney cDNA library. The hOAT3 cDNA consisted of 2179 base pairs that encoded a …

A cDNA encoding the new member of the multispecific organic anion transporter family,
OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method. …

A cDNA encoding a novel multispecific organic anion transporter, OAT4, was isolated from a
human kidney cDNA library. The OAT4 cDNA consisted of 2210 base pairs that encoded a …

Organic anion transporters play important roles in the elimination of a variety of endogenous
substances, xenobiotics and their metabolites from the body. During the last decade, …

In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a
multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% …

ABSTRACT. In uremic patients, various uremic toxins are accumulated and exert various
biologic effects on uremia. Indoxyl sulfate (IS) is one of uremic toxins that is derived from dietary …

Renal excretion is an important elimination pathway for antiviral agents, such as acyclovir (ACV),
ganciclovir (GCV), and zidovudine (AZT). The purpose of this study was to elucidate the …

A cDNA was isolated from the mouse brain that encodes a novel Na + -independent neutral
amino acid transporter. The encoded protein, designated as Asc-1 (asc-type amino acid …