Autophagy is an evolutionary conserved catabolic process involved in several physiological
and pathological processes such as cancer and neurodegeneration. Autophagy initiation …

Apoptosing cells are actively phagocytosed in parenchymal tissues, thus preventing the
inflammatory reaction which could derive from their slow uncontrolled degradation. The …

The retinoblastoma gene product (pRB) plays an important role in controlling both cell release
from the G 1 phase and apoptosis. We show here that in the early phases of apoptosis, …

AIMS: Aloe-emodin (AE), a natural hydroxyanthraquinone compound, has been reported as
a potential anticancer agent. We studied the antineoplastic properties of AE on highly …

Autophagy is a highly conserved cellular process responsible for the degradation of long-lived
proteins and organelles. Autophagy occurs at low levels under normal conditions, but it is …

Treatment of the human promonocytic cell line U937 with all-trans-retinoic acid (RA) commits
these cells to apoptosis, which can be triggered by simply increasing intracellular calcium …

AIMS: Aloe-emodin (AE), a plant derived anthraquinone, has been shown to have anticancer
activity in various human cancer cell lines. We have recently reported that AE possesses a …

The synthetic retinoid fenretinide induces apoptosis of neuroblastoma cells and in vitro acts
synergistically with chemotherapeutic drugs used to treat neuroblastoma. The mechanisms …

Neuroblastomas in culture are characterized by the presence of 2 morphologically and
biochemically distinct phenotypes (ie, neural “N‐type” and flat substrate‐adherent “S‐type”) …

In this study, we have evaluated the potential antineoplastic effects of α-mangostin (α-M),
the most representative xanthone in Garcinia mangostana pericarp, on melanoma cell lines. …