Insulin signaling in the hypothalamus plays a role in maintaining body weight. Studies suggest
that the forkhead transcription factor Foxo1 is an important mediator of insulin signaling in …

Triglyceride accumulation in skeletal muscle contributes to insulin resistance in obesity. We
recently showed that α-lipoic acid (ALA) reduces body weight and prevents the development …

OBJECTIVE—Adiponectin is an important adipocytokine that improves insulin action and
reduces atherosclerotic processes. The plasma adiponectin level is paradoxically reduced in …

Many transcription coactivators interact with nuclear receptors in a ligand- and C-terminal
transactivation function (AF2)-dependent manner. These include activating signal cointegrator …

Multidrug resistance has been a major problem in cancer chemotherapy. In this study, in
vitro and in vivo modulations of MDR by ginsenoside Rg 3 , a red ginseng saponin, were …

INTRODUCTION: AMP-activated protein kinase (AMPK) has been reported to stimulate
differentiation and proliferation of osteoblasts, but the role of AMPK in the physiology of …

Coupling is the process that links bone resorption to bone formation in a temporally and
spatially coordinated manner within the remodeling cycle. Several lines of evidence point to the …

Background Hepatocellular carcinoma (HCC) is the most common tumor in the adult liver,
with high relapse and mortality rates despite diverse treatment modalities. In this study, …

Spread of Streptococcus pneumoniae from the nasopharynx to other host tissues would require
the organism to adapt to a variety of environmental conditions. Since heat shock proteins …

INTRODUCTION: Traumatic chest injuries may occur following cardiopulmonary resuscitation
(CPR). The aim of this study was to address the frequency of injuries, especially rib and …