Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine
S Lobert, B Vulevic, JJ Correia - Biochemistry, 1996 - ACS Publications
Vinca alkaloids are antimitotic drugs that inhibit microtubule assembly and induce tubulin
self-association into coiled spiral aggregates. Previous sedimentation velocity results with …
self-association into coiled spiral aggregates. Previous sedimentation velocity results with …
Analgesic effects of oral sucrose and pacifier during eye examinations for retinopathy of prematurity
…, B Stevens, N Mungan, W Johnson, S Lobert… - Pain Management …, 2004 - Elsevier
Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants, but no
studies have been done to determine the effectiveness of sucrose during eye examinations for …
studies have been done to determine the effectiveness of sucrose during eye examinations for …
β‐tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas
…, A Spano, JJ Correia, S Lobert - Cell Motility and the …, 2008 - Wiley Online Library
Previous studies suggest that β‐tubulin isotype protein levels could be useful as indicators
of nonsmall cell lung cancer (NSCLC) aggressiveness. However, measurement of protein …
of nonsmall cell lung cancer (NSCLC) aggressiveness. However, measurement of protein …
[HTML][HTML] β class II tubulin predominates in normal and tumor breast tissues
…, A Frankfurter, JJ Correia, S Lobert - Breast Cancer …, 2003 - Springer
Background Antimitotic chemotherapeutic agents target tubulin, the major protein in mitotic
spindles. Tubulin isotype composition is thought to be both diagnostic of tumor progression …
spindles. Tubulin isotype composition is thought to be both diagnostic of tumor progression …
A comparison of thermodynamic parameters for vinorelbine-and vinflunine-induced tubulin self-association by sedimentation velocity
S Lobert, JW Ingram, BT Hill, JJ Correia - Molecular pharmacology, 1998 - ASPET
We present a comparison of the energetics of spiral formation for two vinca alkaloids: a
novel difluorinated vinorelbine derivative 20′,20′-difluoro-3′,4′-dihydrovinorelbine (F12158…
novel difluorinated vinorelbine derivative 20′,20′-difluoro-3′,4′-dihydrovinorelbine (F12158…
Comparison of β‐tubulin mRNA and protein levels in 12 human cancer cell lines
…, A Spano, JJ Correia, S Lobert - Cell motility and the …, 2006 - Wiley Online Library
Antimitotic drugs are chemotherapeutic agents that bind tubulin and microtubules. Resistance
to these drugs is a major clinical problem. One hypothesis is that the cellular composition …
to these drugs is a major clinical problem. One hypothesis is that the cellular composition …
Regulation of β‐tubulin isotypes by micro‐RNA 100 in MCF7 breast cancer cells
S Lobert, B Jefferson, K Morris - Cytoskeleton, 2011 - Wiley Online Library
Antimitotic drugs are key components of combination chemotherapy protocols for
hematological and solid tumors. The taxanes (eg, paclitaxel) bind to the β subunit of the tubulin …
hematological and solid tumors. The taxanes (eg, paclitaxel) bind to the β subunit of the tubulin …
Energetics of vinca alkaloid interactions with tubulin
S Lobert, JJ Correia - Methods in enzymology, 2000 - Elsevier
Publisher Summary This chapter presents a detailed discussion of the energetics of
interactions between Vinca rosea L. (vinca) alkaloids, antimitotic chemotherapeutic agents, and …
interactions between Vinca rosea L. (vinca) alkaloids, antimitotic chemotherapeutic agents, and …
Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line
S Lobert, J Fahy, BT Hill, A Duflos, C Etievant… - Biochemistry, 2000 - ACS Publications
The ability of a class of C-20‘ modified vinca alkaloid congeners to induce tubulin spiral
formation was investigated relative to their ability to inhibit microtubule assembly, their …
formation was investigated relative to their ability to inhibit microtubule assembly, their …
Expression profiling of tubulin isotypes and microtubule-interacting proteins using real-time polymerase chain reaction
S Lobert, L Hiser, JJ Correia - Methods in cell biology, 2010 - Elsevier
Real-time polymerase chain reaction (PCR) has been used for quantification of intracellular
mRNA levels in cell culture and tissue samples. It is an important tool for studying antimitotic …
mRNA levels in cell culture and tissue samples. It is an important tool for studying antimitotic …