Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA

S Shimada, S Kitayama, CL Lin, A Patel… - Science, 1991 - science.org
A rat dopamine (DA) transporter complementary DNA has been isolated with combined
complementary DNA homology and expression approaches. The DA transporter is a 619-amino …

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

…, DM Donovan, S Shimada… - Proceedings of the …, 1991 - National Acad Sciences
Type A gamma-aminobutyric acid (GABAA) receptors are a family of ligand-gated chloride
channels that are the major inhibitory neurotransmitter receptors in the nervous system. …

[HTML][HTML] Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors

…, M Nishigaki, Y Shibata, S Shimada - The Journal of …, 2002 - Am Soc Clin Investig
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac
ischemia, and exhausted skeletal muscles are accompanied by local tissue acidosis. In such …

Minimum thickness of cut in micromachining

N Ikawa, S Shimada, H Tanaka - Nanotechnology, 1992 - iopscience.iop.org
The authors discuss the significance of the minimum thickness of cut (MTC) which is defined
as the minimum undeformed thickness of chip removed from a work surface at a cutting …

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

S Kitayama, S Shimada, H Xu… - Proceedings of the …, 1992 - National Acad Sciences
Polar amino acids lying within three hydrophobic regions of the dopamine transporter (DAT)
are analogous to those important for ligand recognition by catecholamine receptors. …

[HTML][HTML] Cloning and functional expression of a brain peptide/histidine transporter

T Yamashita, S Shimada, W Guo, K Sato… - Journal of Biological …, 1997 - ASBMB
Here we report the cloning and functional characterization of a rat novel peptide/histidine
transporter (PHT1), which was expressed in the brain and the retina. The cDNA encodes the …

Feasibility study on ultimate accuracy in microcutting using molecular dynamics simulation

S Shimada, N Ikawa, H Tanaka, G Ohmori, J Uchikoshi… - CIRP annals, 1993 - Elsevier
Using molecular dynamics computer simulation, the feasibility is analyzed or, nanometric or
an ultimate machining accuracy attainable in microcutting of free machining work materials …

Functional interaction between T2R taste receptors and G-protein α subunits expressed in taste receptor cells

…, H Yamamura, Y Imaizumi, S Shimada - Journal of …, 2003 - Soc Neuroscience
Bitter taste perception is a conserved chemical sense against the ingestion of poisonous
substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called …

Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro

…, K Kawakami, S Shimada… - Proceedings of the …, 2010 - National Acad Sciences
The molecular oscillations underlying the generation of circadian rhythmicity in mammals
develop gradually during ontogenesis. However, the developmental process of mammalian …

[HTML][HTML] Inflammation from peripheral organs to the brain: how does systemic inflammation cause neuroinflammation?

Y Sun, Y Koyama, S Shimada - Frontiers in aging neuroscience, 2022 - frontiersin.org
As inflammation in the brain contributes to several neurological and psychiatric diseases, the
cause of neuroinflammation is being widely studied. The causes of neuroinflammation can …