Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
is hypothesized to be driven by an overreacting innate immune response, where the …

The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress
and modulates pro-inflammatory cytokines. As the sepsis syndrome results from the release …

Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and
successive morbidity. In mild TBI (mTBI), however, the extent and persistence of innate …

Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while
no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 …

Thrombin activation of C5 connects thrombosis to inflammation. Complement research in
whole blood ex vivo necessitates anticoagulation, which potentially interferes with the …

Background The gap between demand and supply of kidneys for transplantation necessitates
the use of kidneys from extended criteria donors. Transplantation of these donor kidneys is …

Objectives: The causal role of the prototype alarmin high mobility group box 1 protein in
systemic inflammation and remote organ injury after trauma and shock is established in animal …

Barbiturates are frequently used for the treatment of intracranial hypertension after brain
injury but their application is associated with a profound increase in the infection rate. The …

For detection of cardiac ischemia based on regional pCO 2 measurement, sensor drift becomes
a problem when monitoring over several hours. A real-time drift correction algorithm was …

Purpose: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response
in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early …