We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the
regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. …

AS1411 is a DNA aptamer that is in phase II clinical trials for relapsed or refractory acute
myeloid leukemia and for renal cell carcinoma. AS1411 binds to nucleolin, a protein that is …

B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B
cells that are resistant to apoptosis as a result of bcl2 oncogene overexpression. Studies …

BACKGROUND: Chronic urticaria is caused by a complement fixing, IgG antibody directed
to the α-subunit of the IgE receptor, which is present in 35% to 45% of patients. This …

This study determined the role of PKC-α and associated inducible heat shock protein 70 (iHSP70)
in the repair of mitochondrial function in renal proximal tubular cells (RPTCs) after …

AS1411 is a 26 base unmodified DNA aptamer which is currently in a Phase II clinical trial for
the treatment of acute myeloid leukemia (AML) and will shortly enter a Phase II trial in renal …

4888 Overexpression of the bcl-2 proto-oncogene in breast cancer cells allows the cells to
avoid apoptosis and become resistant to chemotherapeutic drugs. However, the mechanism …

This study determined role of PKC-α and associated inducible heat shock protein70 (iHSP70)
in 27 the repair of mitochondrial function in renal proximal tubular cells (RPTC) following …

AS1411 is a DNA aptamer in phase II clinical trials for relapsed or refractory acute myeloid
leukemia (AML) and renal cell carcinoma. AS1411 binds to nucleolin, a protein which is …

… (The figure was kindly provided by Sridharan Soundararajan and Daniel J. Fernandes of …
(The figure was kindly provided by Sridharan Soundararajan and Daniel J. Fernandes of the …