5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis
The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates,
phosphatidic acid (PA), are implicated in many cell biological processes, including Ras …
phosphatidic acid (PA), are implicated in many cell biological processes, including Ras …
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials
P Bendale, S Olepu, PK Suryadevara… - Journal of medicinal …, 2007 - ACS Publications
Substituted tetrahydroquinolines (THQs) have been previously identified as inhibitors of
mammalian protein farnesyltransferase (PFT). Previously we showed that blocking PFT in the …
mammalian protein farnesyltransferase (PFT). Previously we showed that blocking PFT in the …
2-Oxo-tetrahydro-1, 8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials
S Olepu, PK Suryadevara, K Rivas, K Yokoyama… - Bioorganic & medicinal …, 2008 - Elsevier
A new class of 2-oxo-tetrahydro-1,8-naphthyridine-based protein farnesyltransferase
inhibitors were synthesized and found to inhibit protein farnesyltransferase from the malaria …
inhibitors were synthesized and found to inhibit protein farnesyltransferase from the malaria …
Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin …
…, AM Giddings, RW Wiethe, S Olepu… - Journal of Medicinal …, 2014 - ACS Publications
Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on
different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. …
different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. …
Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound …
…, AM Giddings, RW Wiethe, S Olepu… - Journal of Medicinal …, 2014 - ACS Publications
Compounds acting via the neurotensin receptor type 2 (NTS2) are known to be active in
animal models of acute and chronic pain. To identify novel NTS2 selective analgesics, we …
animal models of acute and chronic pain. To identify novel NTS2 selective analgesics, we …
Structurally simple inhibitors of Lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease
PK Suryadevara, S Olepu, JW Lockman… - Journal of medicinal …, 2009 - ACS Publications
We report structure−activity studies of a large number of dialkyl imidazoles as inhibitors of
Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple …
Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple …
The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2
JB Thomas, AM Giddings, S Olepu, RW Wiethe… - Bioorganic & medicinal …, 2015 - Elsevier
Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesia in
relevant preclinical models. The amide bond in nonpeptide NTS1 antagonists plays a central …
relevant preclinical models. The amide bond in nonpeptide NTS1 antagonists plays a central …
Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents
PK Suryadevara, KK Racherla, S Olepu… - Bioorganic & medicinal …, 2013 - Elsevier
New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as
potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the …
potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the …
Identification of N-{[6-chloro-4-(2, 6-dimethoxyphenyl) quinazolin-2-yl] carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin …
JB Thomas, AM Giddings, S Olepu, RW Wiethe… - Bioorganic & medicinal …, 2015 - Elsevier
Compounds acting via the GPCR neurotensin receptor type 2 (NTS2) display analgesic effects
in relevant animal models. Using a pharmacophore model based on known NT receptor …
in relevant animal models. Using a pharmacophore model based on known NT receptor …
Hybrid pharmacophore design and synthesis of naphthalimide–benzimidazole conjugates as potential anticancer agents
…, B Naga Sheshadri, O Srinivas - Letters in Drug …, 2015 - ingentaconnect.com
Naphthalimide-benzimidazole conjugates were prepared using two different types of spacer
units; either a simple alkane chain or a substituted piperazine moiety with variable alkyl side …
units; either a simple alkane chain or a substituted piperazine moiety with variable alkyl side …