Voltage-gated calcium channels as targets for the treatment of chronic pain

JG McGivern, SI McDonough - Current Drug Targets-CNS & …, 2004 - ingentaconnect.com
This review focuses on the importance of voltage-gated calcium channels in modulating and
controlling the function of peripheral and central neurons involved in nociceptive processing…

[HTML][HTML] Global Nav1. 7 knockout mice recapitulate the phenotype of human congenital indifference to pain

…, JB Rottman, RJ Beiler, AB Malmberg, SI McDonough - PloS one, 2014 - journals.plos.org
Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss
of acute pain perception. The global deletion is reported lethal in mice, however, and studies …

Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC

SI McDonough, KJ Swartz, IM Mintz… - Journal of …, 1996 - Soc Neuroscience
Inhibition of voltage-dependent calcium channels by omega-conotoxin MVIIC (omega-CTx-MVIIC)
was studied in various types of rat neurons. When studied with 5 mM Ba2+ as charge …

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

…, KL Andrews, BD Moyer, SI McDonough… - Journal of medicinal …, 2015 - ACS Publications
Na V 1.7 is a voltage-gated sodium ion channel implicated by human genetic evidence as a
therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula …

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

…, JA Luther, DJ Matson, SI McDonough… - Nature structural & …, 2017 - nature.com
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy,
side effects and risk of addiction. Here, we present a novel class of potent selective, central …

Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness

…, RW Sandrock, P Nelson, SI McDonough… - Molecular …, 2016 - nature.com
A current focus in psychiatric genetics is detection of multiple common risk alleles through
very large genome-wide association study analyses. Yet families do exist, albeit rare, that …

Peptides targeting voltage-gated calcium channels

RS Norton, SI McDonough - Current pharmaceutical design, 2008 - ingentaconnect.com
Many peptides are potent and highly selective blockers or modulators of calcium channel
function, and as such are valuable pharmacological tools and potentially valuable leads for the …

Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons

SI McDonough, BP Bean - Molecular pharmacology, 1998 - ASPET
The antihypertensive agent mibefradil completely and reversibly inhibited T-type calcium
channels in freshly isolated rat cerebellar Purkinje neurons. The potency of mibefradil was …

Interactions among toxins that inhibit N-type and P-type calcium channels

SI McDonough, LM Boland, IM Mintz… - The Journal of general …, 2002 - rupress.org
A number of peptide toxins from venoms of spiders and cone snails are high affinity ligands
for voltage-gated calcium channels and are useful tools for studying calcium channel …

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

…, K Biswas, BD Moyer, SI McDonough… - Journal of medicinal …, 2016 - ACS Publications
There is interest in the identification and optimization of new molecular entities selectively
targeting ion channels of therapeutic relevance. Peptide toxins represent a rich source of …