The “ins” and “outs” of the high‐affinity choline transporter CHT1

FM Ribeiro, SAG Black, VF Prado… - Journal of …, 2006 - Wiley Online Library
Maintenance of acetylcholine (ACh) synthesis depends on the activity of the high‐affinity
choline transporter (CHT1), which is responsible for the reuptake of choline from the synaptic …

[HTML][HTML] Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity

SAG Black, PK Stys, GW Zamponi… - Frontiers in cell and …, 2014 - frontiersin.org
Although it is well established that misfolding of the cellular prion protein (PrP C ) into the β-sheet-rich,
aggregated scrapie conformation (PrP Sc ) causes a variety of transmissible …

Surface expression and function of Cav3.2 T-type calcium channels are controlled by asparagine-linked glycosylation

N Weiss, SAG Black, C Bladen, L Chen… - … -European Journal of …, 2013 - Springer
Low-voltage-activated T-type calcium channels play important roles in neuronal physiology
where they control cellular excitability and synaptic transmission. Alteration in T-type channel …

Choline transporter CHT regulation and function in cholinergic neurons

S AG Black, R Jane Rylett - Central Nervous System Agents in …, 2012 - ingentaconnect.com
Choline uptake into cholinergic nerve terminals by the sodium-dependent high-affinity
choline transporter CHT is essential for providing choline as substrate for synthesis of …

Constitutive high‐affinity choline transporter endocytosis is determined by a carboxyl‐terminal tail dileucine motif

FM Ribeiro, SAG Black, SP Cregan… - Journal of …, 2005 - Wiley Online Library
Maintenance of acetylcholine synthesis depends on the effective functioning of a high‐affinity
sodium‐dependent choline transporter (CHT1). Recent studies have shown that this …

Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking

LK Cuddy, AC Gordon, SAG Black… - Journal of …, 2012 - Soc Neuroscience
Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine
(SIN-1) [peroxynitrite (ONOO − ) donor]; ONOO − can be produced from nitric oxide …

Regulated recycling and plasma membrane recruitment of the high‐affinity choline transporter

FM Ribeiro, M Pinthong, SAG Black… - European Journal of …, 2007 - Wiley Online Library
The high‐affinity choline transporter (CHT1) is responsible for uptake of choline from the
synaptic cleft and supplying choline for acetylcholine synthesis. CHT1 internalization by clathrin…

Diagnosing Alzheimer's Disease from Circulating Blood Leukocytes Using a Fluorescent Amyloid Probe

SAG Black, AA Stepanchuk… - Journal of …, 2022 - content.iospress.com
Background: Toxic amyloid-ß (Aß) peptides aggregate into higher molecular weight assemblies
and accumulate not only in the extracellular space, but also in the walls of blood vessels …

Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite

M Pinthong, SAG Black, FM Ribeiro… - Molecular …, 2008 - ASPET
Excess formation of nitric oxide and superoxide by-products (peroxynitrite, reactive oxygen,
and reactive nitrogen species) attenuates cholinergic transmission potentially having a role …

Impact of oxidative-nitrosative stress on cholinergic presynaptic function

SAG Black, RJ Rylett - Alzheimer's Disease Pathogenesis-Core …, 2011 - books.google.com
Cholinergic neurotransmission plays an essential role in a variety of physiological processes
in both the central and peripheral nervous systems. Cholinergic neurons use the classical …