KCNQ/M currents in sensory neurons: significance for pain therapy

…, M Mistry, M Al-Qatari, SJ Marsh… - Journal of …, 2003 - Soc Neuroscience
Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic
pain. M currents [I K(M) ] play a key role in regulating neuronal excitability, and mutations in …

Relationship between membrane phosphatidylinositol-4, 5-bisphosphate and receptor-mediated inhibition of native neuronal M channels

…, FC Abogadie, DA Brown, SJ Marsh - Journal of …, 2005 - Soc Neuroscience
The relationship between receptor-induced membrane phosphatidylinositol-4′5′-bisphosphate
(PIP 2 ) hydrolysis and M-current inhibition was assessed in single-dissociated rat …

Regulation of M(Kv7.2/7.3) channels in neurons by PIP2 and products of PIP2 hydrolysis: significance for receptor‐mediated inhibition

DA Brown, SA Hughes, SJ Marsh, A Tinker - 2007 - Wiley Online Library
M‐channels are voltage‐gated K+ channels that regulate the excitability of many neurons.
They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 + Kv7.3. Native M‐channels …

4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current

CE Stansfeld, SJ Marsh, JV Halliwell, DA Brown - Neuroscience letters, 1986 - Elsevier
In a subpopulation of rat visceral afferent neurones we have identified a potassium (K) current
which is novel to mammalian neurones. It activates rapidly at potentials positive to −70 mV …

Elevation of intracellular calcium by muscarinic receptor activation induces a block of voltage-activated rat ether-a-go-go channels in a stably transfected cell line.

…, J Ludwig, RM Weseloh, SJ Marsh… - Proceedings of the …, 1996 - National Acad Sciences
We have studied the properties of r-eag voltage-activated potassium channels in a stably
transfected human embryonic kidney cell line. It was found that r-eag channels are rapidly and …

[HTML][HTML] Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings

…, M Thakur, VN Keasberry, SJ Marsh… - Frontiers in molecular …, 2012 - frontiersin.org
M-channels carry slowly activating potassium currents that regulate excitability in a variety
of central and peripheral neurons. Functional M-channels and their Kv7 channel correlates …

Probing the regulation of M (Kv7) potassium channels in intact neurons with membrane-targeted peptides

J Robbins, SJ Marsh, DA Brown - Journal of Neuroscience, 2006 - Soc Neuroscience
M-type (Kv7) potassium channels are closed by Gq/11 G-protein-coupled receptors. Several
membrane- or channel-associated molecules have been suggested to contribute to this …

PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons

S Hughes, SJ Marsh, A Tinker, DA Brown - Pflügers Archiv-European …, 2007 - Springer
The open state of M(Kv7.2/7.3) potassium channels is maintained by membrane
phosphatidylinositol-4,5-bisphosphate (PI(4,5)P 2 ). They can be closed on stimulating receptors that …

Activation and inhibition of neuronal G protein-gated inwardly rectifying K+ channels by P2Y nucleotide receptors

…, JM Fernandez-Fernandez, SJ Marsh, J Simon… - Molecular …, 2004 - ASPET
Neuronal signaling by G protein-coupled P2Y nucleotide receptors is not well characterized.
We studied here the coupling of different molecularly defined P2Y receptors to neuronal G …

Charged precipitation measurements before the first lightning flash in a thunderstorm

SJ Marsh, TC Marshall - Journal of Geophysical Research …, 1993 - Wiley Online Library
On August 15, 1984, we made balloon measurements of the electric field and of the charge
and vertical velocity of precipitation particles in a thunderstorm over Langmuir Laboratory. …