The myelin sheath allows axons to conduct action potentials rapidly in the vertebrate nervous
system. Axonal signals activate expression of specific transcription factors, including Oct6 …

Biomarkers appear to be entities that are everything to everyone. They appear to be amorphous
in shape, size and impact. Enormous interest has been generated in this fledgling arena …

Frataxin deficiency is the primary cause of Friedreich ataxia (FRDA), an autosomal
recessive cardiodegenerative and neurodegenerative disease. Frataxin is a nuclear-encoded …

Diet-induced obesity (DIO) leads to inflammatory activation of macrophages in white adipose
tissue (WAT) and subsequently to insulin resistance. PPARγ agonists are antidiabetic …

The advent of on-line multidimensional liquid chromatography-mass spectrometry has
significantly impacted proteomic analyses of complex biological fluids such as plasma. However, …

Background: Congenital disorders of glycosylation (CDG) are autosomal recessive disorders
that produce increased serum carbohydrate-deficient transferrin (CDT) isoforms. Methods …

The kinesin motor protein Kif1b has previously been implicated in the axonal transport of
mitochondria and synaptic vesicles 1 , 2 . More recently, KIF1B has been associated with …

In the thymus, positive and negative selection shape the T cell repertoire. It has previously
been shown that positive selection, like negative selection, is the result of the interaction of the …

Differential, functional, and mapping proteomic analyses of complex biological mixtures
suffer from a lack of component resolution. Here we describe the application of ion mobility-mass …

The chemical composition of settleable faecal fish waste was determined from fresh manure
samples collected at 12 commercial farms growing rainbow trout Oncorhynchus mykiss in …