The protein histidine phosphatase LHPP is a tumour suppressor
SK Hindupur, M Colombi, SR Fuhs, MS Matter, Y Guri… - Nature, 2018 - nature.com
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized
post-translational modification of proteins 1 , 2 . Here we describe a role of histidine …
post-translational modification of proteins 1 , 2 . Here we describe a role of histidine …
[PDF][PDF] Identification of PGAM5 as a mammalian protein histidine phosphatase that plays a central role to negatively regulate CD4+ T cells
S Panda, S Srivastava, Z Li, M Vaeth, SR Fuhs… - Molecular cell, 2016 - cell.com
Whereas phosphorylation of serine, threonine, and tyrosine is exceedingly well characterized,
the role of histidine phosphorylation in mammalian signaling is largely unexplored. Here …
the role of histidine phosphorylation in mammalian signaling is largely unexplored. Here …
[HTML][HTML] Development of a virtual reality platform for effective communication of structural data in drug discovery
…, S McCloskey, K Milliken, E Leija, SR Fuhs… - Journal of Molecular …, 2019 - Elsevier
In drug discovery, structural knowledge of a target enables structure-based design approaches
and thereby reduces the time and labor required to develop a therapy. Whilst molecular …
and thereby reduces the time and labor required to develop a therapy. Whilst molecular …
Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3. 1
S Srivastava, S Panda, Z Li, SR Fuhs, T Hunter… - Elife, 2016 - elifesciences.org
10.7554/eLife.16093.001 KCa2.1, KCa2.2, KCa2.3 and KCa3.1 constitute a family of mammalian
small- to intermediate-conductance potassium channels that are activated by calcium-…
small- to intermediate-conductance potassium channels that are activated by calcium-…
Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies
…, J Meisenhelder, JJ La Clair, SR Fuhs… - Proceedings of the …, 2021 - National Acad Sciences
In 2015, monoclonal antibodies (mAbs) that selectively recognize the 1-pHis or 3-pHis
isoforms of phosphohistidine were developed by immunizing rabbits with degenerate Ala/Gly …
isoforms of phosphohistidine were developed by immunizing rabbits with degenerate Ala/Gly …
[HTML][HTML] Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization
SR Fuhs, PA Insel - Journal of Biological Chemistry, 2011 - ASBMB
Caveolin (Cav) proteins in the plasma membrane have numerous binding partners, but the
determinants of these interactions are poorly understood. We show here that Cav-3 has a …
determinants of these interactions are poorly understood. We show here that Cav-3 has a …
Pharmacology and signaling properties of epidermal growth factor receptor isoforms studied by bioluminescence resonance energy transfer
HH Schiffer, EC Reding, SR Fuhs, Q Lu, F Piu… - Molecular …, 2007 - ASPET
We have developed a new assay for measuring epidermal growth factor receptor (EGFR)
activation using the bioluminescence resonance energy transfer (BRET) technology, which …
activation using the bioluminescence resonance energy transfer (BRET) technology, which …
[PDF][PDF] Monoclonal 1-and 3-phosphohistidine antibodies: new tools to study histidine phosphorylation
SR Fuhs, J Meisenhelder, A Aslanian, L Ma… - Cell, 2015 - cell.com
Histidine phosphorylation (pHis) is well studied in bacteria; however, its role in mammalian
signaling remains largely unexplored due to the lack of pHis-specific antibodies and the …
signaling remains largely unexplored due to the lack of pHis-specific antibodies and the …
pHisphorylation: the emergence of histidine phosphorylation as a reversible regulatory modification
SR Fuhs, T Hunter - Current opinion in cell biology, 2017 - Elsevier
… Author links open overlay panel Stephen Rush Fuhs , Tony Hunter … Li, SR Fuhs, T.
Hunter, DJ Thiele, SR Hubbard, EY Skolnik … Vaeth, SR Fuhs, T. Hunter, EY Skolnik …
Hunter, DJ Thiele, SR Hubbard, EY Skolnik … Vaeth, SR Fuhs, T. Hunter, EY Skolnik …
[PDF][PDF] Pharmacology and signaling properties of EGFR isoforms studied by Bioluminescence Resonance Energy Transfer (BRET)
HH Schiffer, EC Reding, SR Fuhs, Q Lu, F Piu… - Molecular …, 2006 - Citeseer
We have developed a new assay for measuring epidermal growth factor receptor (EGFR)
activation using the bioluminescence-resonance-energy-transfer (BRET) technology, which …
activation using the bioluminescence-resonance-energy-transfer (BRET) technology, which …