Calcium entry through voltage-gated calcium channels can activate either large- (BK) or
small- (SK) conductance calcium-activated potassium channels. In hippocampal neurons, …

Regulation of N-methyl-d-aspartate (NMDA) receptor activity by kinases and phosphatases
contributes to the modulation of synaptic transmission. Targeting of these enzymes near the …

Compartmentalization of protein kinases with substrates is a mechanism that may promote
specificity of intracellular phosphorylation events. We have cloned a low‐molecular weight A‐…

Second messengers regulate synaptic plasticity by influencing the balance between kinase
and phosphatase activity. One target of this balance is the phosphorylation state of the …

A key step in glutamatergic synapse maturation is the replacement of developmentally
expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that differ in subunit …

Compartmentalization of protein kinases and phosphatases with substrates is a means to
increase the efficacy of signal transduction events. The A-kinaseanchoring protein, AKAP79, is …

Preservation of a balance between synaptic excitation and inhibition is critical for normal
brain function. A number of homeostatic cellular mechanisms have been suggested to play a …

Resensitization of G protein-coupled receptors (GPCR) following prolonged agonist exposure
is critical for restoring the responsiveness of the receptor to subsequent challenges by …

1. An in vitro cellular model of injury was used to elucidate mechanisms contributing to traumatic
brain injury (TBI). Neonatal rat cortical neurons cultured on a flexible silastic membrane …

Tavalin, Steven J., Earl. F. Ellis, and Leslie S. Satin. Inhibition of the electrogenic Na pump
underlies delayed depolarization of cortical neurons after mechanical injury or glutamate. J. …