Progressive transforming growth factor β1–induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor
…, A Murphy, S Chakravarty, S Dugar… - American journal of …, 2005 - atsjournals.org
Pulmonary fibrosis is characterized by chronic scar formation and deposition of extracellular
matrix, resulting in impaired lung function and respiratory failure. Idiopathic pulmonary …
matrix, resulting in impaired lung function and respiratory failure. Idiopathic pulmonary …
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies
…, B Shabane, K Erion, R Masand, S Dugar… - The EMBO …, 2023 - embopress.org
The maintenance of cellular function relies on the close regulation of adenosine triphosphate
(ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is …
(ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial ATP Synthase (CV) is …
Targeting endogenous transforming growth factor β receptor signaling in Smad4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype
…, L Higgins, G McEnroe, S Chakravarty, S Dugar… - Cancer research, 2004 - AACR
Transforming growth factor-β (TGF-β) suppresses tumor formation by blocking cell cycle
progression and maintaining tissue homeostasis. In pancreatic carcinomas, this tumor …
progression and maintaining tissue homeostasis. In pancreatic carcinomas, this tumor …
Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo
…, A Protter, A Murphy, J Chakravarty, S Dugar… - Clinical cancer …, 2006 - AACR
Purpose: Transforming growth factor-β (TGF-β) suppresses tumor development by inhibiting
cellular proliferation, inducing differentiation and apoptosis, and maintaining genomic …
cellular proliferation, inducing differentiation and apoptosis, and maintaining genomic …
2-Azetidinone cholesterol absorption inhibitors: structure− activity relationships on the heterocyclic nucleus
…, MA Caplen, MS Domalski, S Dugar… - Journal of medicinal …, 1996 - ACS Publications
A series of azetidinone cholesterol absorption inhibitors related to SCH 48461 ((−)-6) has
been prepared, and compounds were evaluated for their ability to inhibit hepatic cholesteryl …
been prepared, and compounds were evaluated for their ability to inhibit hepatic cholesteryl …
Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model
…, J Axon, A Murphy, S Chakravarty, S Dugar… - Neuro …, 2007 - academic.oup.com
Transforming growth factor-β (TGF-β) is a proinvasive and immunosuppressive cytokine that
plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling …
plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling …
p38α-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation
…, JY Ma, AM Kapoun, S Chakravarty, S Dugar… - … of Pharmacology and …, 2008 - ASPET
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary inflammation,
which is relatively insensitive to inhaled corticosteroids. The extent of the pulmonary …
which is relatively insensitive to inhaled corticosteroids. The extent of the pulmonary …
(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy
Introduction We conducted an open‐label study to examine the effects of the flavonoid (−)‐epicatechin
in seven ambulatory adult patients with Becker muscular dystrophy (BMD). …
in seven ambulatory adult patients with Becker muscular dystrophy (BMD). …
A randomized, placebo-controlled, double-blind study on the effects of (−)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with …
…, MA Lanaspa, C Cicerchi, RJ Johnson, S Dugar… - International journal of …, 2016 - Elsevier
Background Cardiometabolic disruptions such as insulin resistance, obesity, high blood
pressure, hyperglycemia, and dyslipidemias, are known to increase the risk for cardiovascular …
pressure, hyperglycemia, and dyslipidemias, are known to increase the risk for cardiovascular …
Antinociceptive action of a p38α MAPK inhibitor, SD-282, in a diabetic neuropathy model
SM Sweitzer, S Medicherla, R Almirez, S Dugar… - Pain, 2004 - journals.lww.com
Diabetes can induce a bewildering list of sensory changes, including alteration in pain
sensitivity. Painful diabetic neuropathy is refractory to most common analgesics. This study …
sensitivity. Painful diabetic neuropathy is refractory to most common analgesics. This study …