Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

…, A Breton, F Tandia, A Linteau, S Sillaots… - Molecular …, 2003 - Wiley Online Library
Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs
to combat fungal infections [Sobel, JD (2000) Clin Infectious Dis 30: 652], antifungal drug …

[HTML][HTML] Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans

…, K Veillette, N Martel, J Davison, S Sillaots… - PLoS …, 2007 - journals.plos.org
Candida albicans is a prevalent fungal pathogen amongst the immunocompromised
population, causing both superficial and life-threatening infections. Since C. albicans is diploid, …

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

…, J Tam, H Wang, TC Meredith, S Sillaots… - Science translational …, 2012 - science.org
Despite the need for new antibiotics to treat drug-resistant bacteria, current clinical combinations
are largely restricted to β-lactam antibiotics paired with β-lactamase inhibitors. We have …

[HTML][HTML] Essential gene identification and drug target prioritization in Aspergillus fumigatus

W Hu, S Sillaots, S Lemieux, J Davison… - PLoS …, 2007 - journals.plos.org
Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans,
causing severe and often fatal invasive infections in immunocompromised patients. …

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

…, M Hauser, L Huang, M Lin, S Sillaots… - Proceedings of the …, 2010 - National Acad Sciences
One potentially rich source of possible targets for antifungal therapy are those Candida
albicans genes deemed essential for growth under the standard culture (ie, in vitro) conditions; …

[PDF][PDF] Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics

SH Lee, LW Jarantow, H Wang, S Sillaots, H Cheng… - Chemistry & biology, 2011 - cell.com
Antibiotic drug resistance among hospital and community acquired methicillin resistant
Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current therapeutics. We …

[PDF][PDF] Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus

…, D Xu, K Veillette, J Davison, S Sillaots… - Chemistry & biology, 2007 - cell.com
Mechanism-of-action (MOA) studies of bioactive compounds are fundamental to drug discovery.
However, in vitro studies alone may not recapitulate a compound's MOA in whole cells. …

[HTML][HTML] Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans

D Xu, S Sillaots, J Davison, W Hu, B Jiang… - Journal of biological …, 2009 - ASBMB
The balance between saturated and unsaturated fatty acids plays a crucial role in determining
the membrane fluidity. In the diploid fungal pathogen Candida albicans, the gene for fatty …

[PDF][PDF] PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products

…, J Allocco, C Parish, J Davison, K Veillette, S Sillaots… - Chemistry & biology, 2008 - cell.com
Natural products provide an unparalleled source of chemical scaffolds with diverse biological
activities and have profoundly impacted antimicrobial drug discovery. To further explore …

Plasmid vectors for protein production, gene expression and molecular manipulations in Aspergillus niger

R Storms, Y Zheng, H Li, S Sillaots, A Martinez-Perez… - Plasmid, 2005 - Elsevier
We constructed three sets of plasmids for use in Aspergillus niger. These plasmids were
assembled using various combinations of a series of modular DNA cassettes that included a …