… following seizures might direct blood leukocytes into the brain, 92 which would be consistent
with the reported emergence of granulocytes during epileptogenesis, 63,92 and sparse T …

The role of peptides as signalling molecules in the nervous system has been studied for more
than 30 years. Neuropeptides and their G-protein-coupled receptors are widely distributed …

… are the findings that cell penetrating ceramide analogs such as C2 ceramide can in vivo
mediate fever like rise in temperature when applied intracerebroventricularly (Bartfai et al., …

Interleukin (IL)-1β is a proinflammatory cytokine implicated in various pathophysiological
conditions of the CNS involving NMDA receptor activation. Circumstantial evidence suggests …

… City, CA) peptide synthesizer using the t-Boc strategy of solid phase peptide synthesis“.
PNA oligomers were synthesized manually” using the tBoc strategy. The purity of peptides and …

The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of
amyloid deposits, and contributes to the pathogenesis of amyloidosis. In order to intervene in …

IL-1β and its endogenous receptor antagonist (IL-1Ra) are rapidly induced by seizures in
the rodent hippocampus. Exogenously applied IL-1β prolongs seizures in an IL-1R type I-…

… Differences among groups were analyzed using Student's t test or one-way analysis of
variance, as appropriate, followed by Bonferroni post hoc test. Significance = 0.05. Values are …

Interleukin (IL)-6, IL-1 beta, and tumor necrosis factor alpha (TNF-alpha) are considered to
act as endogenous pyrogens. Because of the complex pattern of cross-inductions between …

Background Alzheimer disease (AD) is the most common form of dementia but the identification
of reliable, early and non-invasive biomarkers remains a major challenge. We present a …