A long-term goal of cancer diagnosis is to develop tumor-imaging techniques that have
sufficient specificity and sensitivity. To achieve this goal, minimizing the background signal …

A diverse array of small molecule–based fluorescent probes is available for many different
types of biological experiments. Here we examine the history of these probes and discuss …

Nitric oxide is a gaseous, free radical which plays a role as an intracellular second messenger
and a diffusable intercellular messenger. To obtain direct evidence for NO functions in vivo…

We designed and synthesized 2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic
acid (HPF) and 2- [6-(4′-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid (APF) as novel …

Fluorescence imaging is the most powerful technique currently available for continuous
observation of dynamic intracellular processes in living cells. Suitable fluorescence probes are …

… Tetsuo Nagano … Nagano et al. succeeded in NO imaging on the surface of rat brain (unpublished
data). In section III, we will review the development of workable probes for bioimaging of NO …

Photosensitizers are reagents that produce reactive oxygen species upon light illumination
and are commonly used to study oxidative stress or for photodynamic therapy. There are …

To characterize fullerenes (C 60 and C 70 ) as photosensitizers in biological systems, the
generation of active oxygen species, through energy transfer (singlet oxygen 1 O 2 ) and …

Boron dipyrromethene (BODIPY) is known to have a high quantum yield (ϕ) of fluorescence
in aqueous solution but has not been utilized much for biological applications, compared to …

Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2,
and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively. …