Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes
…, Y Hama, Y Koyama, T Barrett, M Kamiya, T Nagano… - Nature medicine, 2009 - nature.com
A long-term goal of cancer diagnosis is to develop tumor-imaging techniques that have
sufficient specificity and sensitivity. To achieve this goal, minimizing the background signal …
sufficient specificity and sensitivity. To achieve this goal, minimizing the background signal …
Fluorescent probes for sensing and imaging
T Ueno, T Nagano - Nature methods, 2011 - nature.com
A diverse array of small molecule–based fluorescent probes is available for many different
types of biological experiments. Here we examine the history of these probes and discuss …
types of biological experiments. Here we examine the history of these probes and discuss …
Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins
…, Y Kirino, H Nagoshi, Y Hirata, T Nagano - Analytical …, 1998 - ACS Publications
Nitric oxide is a gaseous, free radical which plays a role as an intracellular second messenger
and a diffusable intercellular messenger. To obtain direct evidence for NO functions in vivo…
and a diffusable intercellular messenger. To obtain direct evidence for NO functions in vivo…
[HTML][HTML] Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species* 210
…, Y Urano, K Kakinuma, HJ Majima, T Nagano - Journal of Biological …, 2003 - ASBMB
We designed and synthesized 2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic
acid (HPF) and 2- [6-(4′-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid (APF) as novel …
acid (HPF) and 2- [6-(4′-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid (APF) as novel …
Evolution of fluorescein as a platform for finely tunable fluorescence probes
Fluorescence imaging is the most powerful technique currently available for continuous
observation of dynamic intracellular processes in living cells. Suitable fluorescence probes are …
observation of dynamic intracellular processes in living cells. Suitable fluorescence probes are …
Bioimaging of nitric oxide
T Nagano, T Yoshimura - Chemical reviews, 2002 - ACS Publications
… Tetsuo Nagano … Nagano et al. succeeded in NO imaging on the surface of rat brain (unpublished
data). In section III, we will review the development of workable probes for bioimaging of NO …
data). In section III, we will review the development of workable probes for bioimaging of NO …
Highly efficient and photostable photosensitizer based on BODIPY chromophore
…, Y Ishitsuka, F Maniwa, T Nagano - Journal of the …, 2005 - ACS Publications
Photosensitizers are reagents that produce reactive oxygen species upon light illumination
and are commonly used to study oxidative stress or for photodynamic therapy. There are …
and are commonly used to study oxidative stress or for photodynamic therapy. There are …
Active Oxygen Species Generated from Photoexcited Fullerene (C60) as Potential Medicines: O2-• versus 1O2
…, Y Goda, T Masumizu, T Nagano - Journal of the …, 2003 - ACS Publications
To characterize fullerenes (C 60 and C 70 ) as photosensitizers in biological systems, the
generation of active oxygen species, through energy transfer (singlet oxygen 1 O 2 ) and …
generation of active oxygen species, through energy transfer (singlet oxygen 1 O 2 ) and …
Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore rational design of potentially useful bioimaging fluorescence probe
…, K Kikuchi, H Kojima, T Nagano - Journal of the American …, 2004 - ACS Publications
Boron dipyrromethene (BODIPY) is known to have a high quantum yield (ϕ) of fluorescence
in aqueous solution but has not been utilized much for biological applications, compared to …
in aqueous solution but has not been utilized much for biological applications, compared to …
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
…, M Shirouzu, H Ogata, K Tokuyama, K Ueki, T Nagano… - Nature, 2013 - nature.com
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2,
and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively. …
and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively. …