Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery …

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing …

Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein-receptor kinases
are involved in the desensitization of several G protein-coupled receptors (GPCR). However, …

The delivery of biologic cargoes to airway epithelial cells is challenging due to the formidable
barriers imposed by its specialized and differentiated cells. Among cargoes, recombinant …

Delivery of recombinant proteins to therapeutic cells is limited by a lack of efficient methods.
This hinders the use of transcription factors or Clustered Regularly Interspaced Short …

Inhibition of glycogen synthase kinase 3β (GSK3β) is a shared action believed to be involved
in the regulation of behavior by psychoactive drugs such as antipsychotics and mood …

Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified
in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia…

Rationale Psychostimulants such as amphetamine and methylphenidate, which target the
dopamine transporter (DAT), are the most frequently used drugs for the treatment of …

Mood stabilizers are a heterogeneous class of drugs having antidepressant and anti-manic
effects in bipolar disorders, depression and schizophrenia. Despite wide clinical applications…

Mental illnesses such as bipolar disorders, ADHD, depression and schizophrenia are a
major public health concern worldwide. While several pharmacological agents acting on …