User profiles for Thomas J. Raub
Thomas J RaubRetired Verified email at iu.edu Cited by 8460 |
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
IJ Hidalgo, TJ Raub, RT Borchardt - Gastroenterology, 1989 - Elsevier
Caco-2 cells develop morphologic characteristics of normal enterocytes when grown on plastic
dishes or nitrocellulose filters. The purpose of this study was to determine whether Caco-…
dishes or nitrocellulose filters. The purpose of this study was to determine whether Caco-…
Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
A Adson, TJ Raub, PS Burton, CL Barsuhn… - Journal of …, 1994 - Elsevier
When using cultured cell monolayers to determine the mechanism of transcellular diffusion
of molecules, it may be important to identify the fraction that moves through the paracellular …
of molecules, it may be important to identify the fraction that moves through the paracellular …
Brain exposure of two selective dual CDK4 and CDK6 inhibitors and the antitumor activity of CDK4 and CDK6 inhibition in combination with temozolomide in an …
TJ Raub, GN Wishart, P Kulanthaivel, BA Staton… - Drug Metabolism and …, 2015 - ASPET
Effective treatments for primary brain tumors and brain metastases represent a major unmet
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …
P-glycoprotein recognition of substrates and circumvention through rational drug design
TJ Raub - Molecular pharmaceutics, 2006 - ACS Publications
It is now well recognized that membrane efflux transporters, especially P-glycoprotein (P-gp;
ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and …
ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and …
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment …
…, EHF Wong, BA Staton, TJ Raub… - Journal of medicinal …, 2006 - ACS Publications
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a
novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been …
novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been …
Determination of the affinity of drugs toward serum albumin by measurement of the quenching of the intrinsic tryptophan fluorescence of the protein
Binding of new chemical entities to serum proteins is an issue confronting pharmaceutical
companies during development of potential therapeutic agents. Most drugs bind to the most …
companies during development of potential therapeutic agents. Most drugs bind to the most …
Passive diffusion of weak organic electrolytes across Caco‐2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers
A Adson, PS Burton, TJ Raub, CL Barsuhn… - Journal of …, 1995 - Elsevier
A systematic approach was used to demonstrate the quantitative interplay of pH, pK a ,
lipophilicity, charged and uncharged molecular species, molecular size, aqueous diffusivity, and …
lipophilicity, charged and uncharged molecular species, molecular size, aqueous diffusivity, and …
[HTML][HTML] How hydrogen bonds impact P-glycoprotein transport and permeability
The requirement to cross a biological membrane can be a complex process especially if
multidrug transporters such as P-gp must be considered. Drug partitioning into the lipid …
multidrug transporters such as P-gp must be considered. Drug partitioning into the lipid …
Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells
TJ Raub, SL Kuentzel, GA Sawada - Experimental cell research, 1992 - Elsevier
It has been shown both in vivo and in culture that astrocytes communicate with brain microvessel
endothelial cells (BMECs) to induce many of the blood—brain barrier characteristics …
endothelial cells (BMECs) to induce many of the blood—brain barrier characteristics …
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
…, BA Olson, L Fitzgerald, BA Staton, TJ Raub… - Bioorganic & medicinal …, 2006 - Elsevier
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists
of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability …
of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability …