The crystal structure of staphylococcal nuclease has been determined to 1.7 Å resolution
with a final R‐factor of 16.2% using stereochemically restrained Hendrickson–Konnert least‐…

Background: Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate
for glycolysis. Maintaining control of blood glucose levels is critical in minimizing …

Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate, which
enters glycolysis to fulfill the energetic requirements of the organism. Maintaining control …

The crystal structures of the inhibitor domain of Alzheimer's amyloid β‐protein precursor (APPI)
complexed to bovine chymotrypsin (C‐APPI) and trypsin (T‐APPI) and basic pancreatic …

To visualize and investigate the regulation of the localization patterns of G s and an associated
receptor during cell signaling, we produced functional fluorescent fusion proteins and …

Mimics of the benzimidazolone nucleus found in inhibitors of p38 kinase are proposed, and
their theoretical potential as bioisosteres is described. A set of calculated descriptors …

Alzheimer’s amyloid/3-protein precursor contains a Kunitz protease inhibitor domain (APPI)
potentially involved in proteolytic events leadingto cerebral amyloid deposition. To facilitate …

We have used the Nitella-based movement assay to localize the site of force production in
myosin. Methods were developed to use nonfilamentous myosin or proteolytic fragments of …

To investigate the role of subcellular localization in regulating the specificity of G protein βγ
signaling, we have applied the strategy of bimolecular fluorescence complementation (BiFC) …

The crystal structure of the Fab fragment of the murine monoclonal anti-dinitrophenyl-spin-label
antibody AN02 complexed with its hapten has been solved at 2·9Åresolution using a …