User profiles for Thomas Steinkellner
Thomas SteinkellnerMedical University of Vienna Verified email at meduniwien.ac.at Cited by 1052 |
[PDF][PDF] VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release
Like ventral tegmental area (VTA) dopamine (DA) neurons, VTA glutamate neuron activity
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and d-amphetamine
Amphetamine (‘Speed’), methamphetamine (‘Ice’) and its congener 3,4-methylenedioxymethamphetamine
(MDMA; ‘Ecstasy’) are illicit drugs abused worldwide for their euphoric and …
(MDMA; ‘Ecstasy’) are illicit drugs abused worldwide for their euphoric and …
[HTML][HTML] The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters
S Bulling, K Schicker, YW Zhang, T Steinkellner… - Journal of Biological …, 2012 - ASBMB
Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has
been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other …
been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other …
[HTML][HTML] Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons
Parkinson’s disease is characterized by the loss of dopamine (DA) neurons in the substantia
nigra pars compacta (SNc). DA neurons in the ventral tegmental area are more resistant to …
nigra pars compacta (SNc). DA neurons in the ventral tegmental area are more resistant to …
Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4, 5-bisphosphate
…, K Schicker, T Steinkellner… - Proceedings of the …, 2013 - National Acad Sciences
Nerve functions require phosphatidylinositol-4,5-bisphosphate (PIP 2 ) that binds to ion
channels, thereby controlling their gating. Channel properties are also attributed to serotonin …
channels, thereby controlling their gating. Channel properties are also attributed to serotonin …
[HTML][HTML] Ca2+/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome
T Steinkellner, JW Yang, TR Montgomery… - Journal of Biological …, 2012 - ASBMB
The dopamine transporter (DAT) is a crucial regulator of dopaminergic neurotransmission,
controlling the length and brevity of dopaminergic signaling. DAT is also the primary target of …
controlling the length and brevity of dopaminergic signaling. DAT is also the primary target of …
[HTML][HTML] In vivo amphetamine action is contingent on αCaMKII
T Steinkellner, L Mus, B Eisenrauch… - …, 2014 - nature.com
Addiction to psychostimulants (ie, amphetamines and cocaine) imposes a major socioeconomic
burden. Prevention and treatment represent unmet medical needs, which may be …
burden. Prevention and treatment represent unmet medical needs, which may be …
Binding mode selection determines the action of ecstasy homologs at monoamine transporters
…, YW Zhang, J Cao, M Holy, T Steinkellner… - Molecular …, 2016 - ASPET
Determining the structural elements that define substrates and inhibitors at the monoamine
transporters is critical to elucidating the mechanisms underlying these disparate functions. In …
transporters is critical to elucidating the mechanisms underlying these disparate functions. In …
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration
Age is the greatest risk factor for Parkinson's disease (PD) which causes progressive loss of
dopamine (DA) neurons, with males at greater risk than females. Intriguingly, some DA …
dopamine (DA) neurons, with males at greater risk than females. Intriguingly, some DA …
Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure
Psychiatric disease often produces symptoms that have divergent effects on neural activity.
For example, in drug dependence, dysfunctional value-based decision-making and …
For example, in drug dependence, dysfunctional value-based decision-making and …