The general phenylpropanoid metabolism generates an enormous array of secondary
metabolites based on the few intermediates of the shikimate pathway as the core unit. The …

Notch receptors function in highly conserved intercellular signalling pathways that direct cell-fate
decisions, proliferation and apoptosis in metazoans. Fringe proteins can positively and …

Background It is known that obesity, sodium intake, and alcohol consumption influence blood
pressure. In this clinical trial, Dietary Approaches to Stop Hypertension, we assessed the …

Context.—Alendronate sodium reduces fracture risk in postmenopausal women who have
vertebral fractures, but its effects on fracture risk have not been studied for women without …

Progress in public health and community-based interventions has been hampered by the
lack of a comprehensive evaluation framework appropriate to such programs. Multilevel …

Background Many risk factors for hip fractures have been suggested but have not been
evaluated in a comprehensive prospective study. Methods We assessed potential risk factors, …

To determine whether measurement of bone density predicts hip fracture in women, we
prospectively studied 9703 nonblack women aged 65 years and older who had measurements …

Melanomas are highly heterogeneous tumors, but the biological significance of their
different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-…

Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. To elucidate
the molecular basis of NAFLD, we performed an exome-wide association study of liver …

Background: The difficulties in accurately assessing pigmented skin lesions are ever present
in practice. The recently described ABCD rule of dermatoscopy (skin surface microscopy at …