Aquaporin-1 (AQP1) is a member of the membrane intrinsic protein (MIP) gene family and is
known to provide pathways for water flux across cell membranes. We show here that cloned …

The kinetics of drug-receptor interactions can profoundly influence in vivo and in vitro
pharmacology. In vitro, the potencies of slowly associating agonists may be underestimated in …

PURPOSE: Prostaglandin F2 alpha (PGF2 alpha) and analogs, such as latanoprost, are thought
to lower intraocular pressure (IOP), primarily by increasing uveoscleral outflow. However…

methods. The right eye of 15 mice received a single subconjunctival injection of a 1.5-μL
solution of 0.25% 70-kDa tetramethylrhodamine-dextran (TMR-D). The distribution of …

purpose. To determine the effect of treatment with latanoprost on the tissue inhibitors of
metalloproteinase (TIMP)-1 and-2 in cultured human ciliary muscle (HCM) cells. methods. …

purpose. To examine the expression of five prostaglandin (PG) receptors, EP 1, EP 2, EP 3,
EP 4, and FP and their corresponding mRNA transcripts in human sclera and cultured …

Previous studies have shown that the guinea pig inferior mesenteric artery receives spinal
sensory vasodilatory innervation, which can be activated by colon distention and electrical …

The results of molecular cloning have revealed three subtypes of the α 2 -adrenergic receptors
(α 2 AR) that have been defined α 2 C10 (α 2A ), α 2 C2 (α 2B ) and α 2 C4 (α 2C ). The …

Purpose. To determine the expression and functional coupling of EP prostanoid receptor
subtypes to second messenger pathways in bovine ciliary epithelium. Methods. Primary …

The FP A and FP B prostanoid receptor isoforms are G-protein-coupled receptors that are
activated by prostaglandin F 2α (PGF 2α ). Differences in their carboxyl termini prompted us to …