Influence of environmental temperature on the induction of xenobiotic metabolism by β-naphthoflavone in rainbow trout, Salmo gairdneri

T Andersson, U Koivusaari - Toxicology and applied pharmacology, 1985 - Elsevier
… 2 shows that maximum responses of EC- and ER-U-deethylases, assayed at 17”C, to
BNF treatment were obtained at a dose of 5 mg/kg or above in coldand warm-acclimated fish, …

Influence of biological and environmental factors on hepatic steroid and xenobiotic metabolism in fish: interaction with PCB and β-naphthoflavone

L Förlin, T Andersson, U Koivusaari… - Marine Environmental …, 1984 - Elsevier
The degree of induction of hepatic cytochrome P-450 monooxygenases in fish by various
chemicals may vary owing to many factors such as sex, sexual maturity, age, season and …

Thermal acclimatization of hepatic polysubstrate monooxygenase and UDP‐ glucuronosyltransferase of mature rainbow trout (Salmo gairdneri)

U Koivusaari - Journal of experimental zoology, 1983 - Wiley Online Library
… temperature similar to 7-ethoxycoumarin-0-deethylase and benzo(a)pyrene hydroxylase,
being significantly higher in cold-acclimated than in warm-acclimated fish (Koivusaari, …

Metabolism of foreign compounds in freshwater crayfish (Astacus astacus L.) tissues

P Lindström-Seppä, U Koivusaari, O Hänninen - Aquatic toxicology, 1983 - Elsevier
Freshwater crayfish, Astacus astacus L. were found to have considerable amounts of
cytochrome P-450 in the hepatopancreas microsomes. The content was almost as high as in rat …

Oxidative and conjugative metabolism of xenobiotics in isolated liver cells from thermally acclimated rainbow trout

T Andersson, U Koivusaari - Aquatic Toxicology, 1986 - Elsevier
… Statistical differences between cold- and warm-acclimated groups were tested for each
incubation temperature, using combined test for two-tailed Mann-Whitney Utest. When enzyme …

Xenobiotic biotransformation in the rainbow trout liver and kidney during starvation

T Andersson, U Koivusaari, L Förlin - Comparative Biochemistry and …, 1985 - Elsevier
… transferase activities were measured according to Koivusaari (1983) and aminopyrine
demethylase activity was measured as … U test and the significance levels were set at P < 0.05. …

Catalytic and immunological comparison of coumarin 7-hydroxylation in different species.

P Kaipainen, U Koivusaari, M Lang - Comparative Biochemistry and …, 1985 - europepmc.org
Coumarin 7-hydroxylation activities were determined in the liver microsomes of eight different
species: pig, mouse (three strains), rat, hamster, guinea-pig, rabbit, rainbow trout and …

Polysubstrate monooxygenase activity and sex hormones in pre-and postspawning rainbow trout (Salmo gairdneri)

U Koivusaari, M Pesonen, O Hänninen - Aquatic toxicology, 1984 - Elsevier
… system was used (final concentrations in incubation mixture: 0.45 mM NADP, 5 mM trisodium
salt of isocitric acid, 75 mM Tris-HC1, 22 mM KC1, 5 mM MgC12, 5 /~M MnCl2 and 0.24 U

Hepatic drug metabolism during ethanol ingestion in riboflavin deficient rats

E Hietanen, U Koivusaari, M Laitinen, A Norling - Toxicology, 1980 - Elsevier
Riboflavin deficiency was induced by feeding rats a riboflavin-deficient diet for 1 month. In
order to find out if there are any combined effects of ethanol and riboflavin deficiency on drug …

Increased fluidity of a model membrane caused by tetrahydro-beta-carbolines.

P Peura, P Mackenzie, U Koivusaari, M Lang - Molecular Pharmacology, 1982 - ASPET
Alterations in membrane fluidity caused by alcohols and tetrahydro-beta-carbolines (THBCs)
have been studied. Dipalmitoylphosphatidylcholine vesicles were used as a membrane …