The use of neural progenitor cells (NPCs) is limited by the incomplete knowledge of the
extracellular signals regulating their proliferation and survival. We report that cultured mouse …

Background Reelin (RELN) is a glycoprotein secreted preferentially by cortical γ-aminobutyric
acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors …

Metabotropic glutamate (mGlu) receptors have been implicated in the regulation of
developmental plasticity. Here, we examined the expression of mGlu1a–b, -2, -3, -4a–b, and -5a …

OBJECTIVE: Murine neural stem cells (NSCs) were homografted onto the injured spinal cord
(SC) to assess their potential to improve motor behavior, to differentiate as neurons, and to …

Exposure of immature rat cerebellar granule cell cultures to the type 4 metabotropic
glutamate (mGlu4) receptor enhancer N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-…

An overactivation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)/kainate
receptors has been implicated in the pathophysiology of oligodendrocyte damage in …

We have applied subtype-selective antagonists of metabotropic glutamate (mGlu) receptors
mGlu1 or mGlu5 [7-(hydroxy-imino) cyclopropa[b]chromen-1a-carboxylate ethyl ester (…

… was also elevated in the striatum, cerebral cortex, CA1 and CA3 hippocampal subfields and
thalamic nuclei of aged rats suggesting that, at least in these regions, an increased de novo …

Objectives: In vitro, neural stem cells (NSCs) proliferate as undifferentiated spheroids and
differentiate into neurons, astrocytes and oligodendrocytes. These features make NSCs …

We examined the role of G-protein coupled receptor kinase-2 (GRK2) in the homologous
desensitization of mGlu4 metabotropic glutamate receptors transiently expressed in human …