[**] We thank Dr. Vladislav Litosh for carrying out preliminary work. Support from the
National Institutes of Health, National Institute of General Medical Sciences (GM 28384), the …

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly
converted into 1, 4-disubstituted 1, 2, 3-triazoles through a highly efficient and regioselective …

oxygen, requiring only stoichiometric amounts of starting materials, and generating virtually
no by-products. Equally important is the wide scope, high selectivity, and nearly quantitative …

Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react
with azides and nitrile oxides, providing ready access to 1,4-disubstituted 1,2,3-triazoles and …

… Valery V. Fokin received his undergraduate education at the University of Nizhny Novgorod,
Russia, and his PhD degree at the University of Southern California under the tutelage of …

The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently
in aqueous solution in the presence of a tris(triazolyl)amine ligand. The process has been …

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and
alkynes. The C 3 -symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for …

Water is the lingua franca of life on our planet and is the solvent of choice for Nature to carry
out her syntheses. 1 In contrast, our methods of making complex organic molecules have …

… Fokin … Valery V. Fokin - Department of Chemistry, The Hong Kong University of
Science and Technology, Clear Water Bay, Kowloon, Hong Kong, and Department of …

The catalytic activity of a series of ruthenium(II) complexes in azide−alkyne cycloadditions
has been evaluated. The [Cp*RuCl] complexes, such as Cp*RuCl(PPh 3 ) 2 , Cp*RuCl(COD), …