User profiles for Vardan T. Karamyan
Vardan T. KaramyanOakland University | William Beaumont School of Medicine Verified email at oakland.edu Cited by 2265 |
[HTML][HTML] Intraperitoneal route of drug administration: should it be used in experimental animal studies?
Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice
in many in vivo studies of disease models. While this route is an easy to master, quick, …
in many in vivo studies of disease models. While this route is an easy to master, quick, …
Animal models of BMAA neurotoxicity: a critical review
VT Karamyan, RC Speth - Life sciences, 2008 - Elsevier
Of all the molecules reported to have toxicological effects, BMAA (beta-methylamino alanine)
stands out as having the most checkered past. In the late 1960’s it was reported to be a …
stands out as having the most checkered past. In the late 1960’s it was reported to be a …
Evidence that γ-secretase-mediated notch signaling induces neuronal cell death via the nuclear factor-κB-Bcl-2-interacting mediator of cell death pathway in ischemic …
…, VT Karamyan, SC Tang, SL Chan, T Magnus… - Molecular …, 2011 - ASPET
Notch-1 (Notch) is a cell surface receptor that regulates cell-fate decisions in the developing
nervous system, and it may also have roles in synaptic plasticity in the adult brain. Binding …
nervous system, and it may also have roles in synaptic plasticity in the adult brain. Binding …
[HTML][HTML] Enzymatic pathways of the brain renin–angiotensin system: unsolved problems and continuing challenges
VT Karamyan, RC Speth - Regulatory peptides, 2007 - ncbi.nlm.nih.gov
The brain renin–angiotensin system continues to be enigmatic more than 40 years after the
brain was first recognized to be a site of action of angiotensin II. This review focuses on the …
brain was first recognized to be a site of action of angiotensin II. This review focuses on the …
Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke
…, S Jayaraman, J Guindon, VT Karamyan - Behavioural brain …, 2018 - Elsevier
Improvement of impaired neurological function(s) is a primary endpoint in experimental
stroke recovery studies, making the choice and nature of the functional tests crucial for proper …
stroke recovery studies, making the choice and nature of the functional tests crucial for proper …
Opioid receptor agonists reduce brain edema in stroke
Cerebral edema is a leading cause of mortality in stroke patients. The purpose of this study
was to assess a non-selective opioid receptor agonist, biphalin, in decreasing reducing brain …
was to assess a non-selective opioid receptor agonist, biphalin, in decreasing reducing brain …
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
VT Karamyan - Physiological Reports, 2021 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming …
coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming …
Functional up‐regulation of endopeptidase neurolysin during post‐acute and early recovery phases of experimental stroke in mouse brain
…, TJ Abbruscato, VT Karamyan - Journal of …, 2014 - Wiley Online Library
In this study, we provide evidence for the first time that membrane‐bound endopeptidase
neurolysin is up‐regulated in different parts of mouse brain affected by focal ischemia‐…
neurolysin is up‐regulated in different parts of mouse brain affected by focal ischemia‐…
2-Methoxyestradiol binding of GPR30 down-regulates angiotensin AT1 receptor
…, U Gumaste, VT Karamyan, T Thekkumkara - European journal of …, 2014 - Elsevier
Controlling angiotensin AT 1 receptor function has been shown to be protective for many
pathophysiological disorders. Although estrogen metabolite, 2-methoxyestradiol (2ME2) can …
pathophysiological disorders. Although estrogen metabolite, 2-methoxyestradiol (2ME2) can …
Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice
…, TJ Abbruscato, VT Karamyan - Journal of …, 2020 - Wiley Online Library
Previous studies documented up‐regulation of peptidase neurolysin (Nln) after brain ischemia,
however, the significance of Nln function in the post‐stroke brain remained unknown. …
however, the significance of Nln function in the post‐stroke brain remained unknown. …