Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice
in many in vivo studies of disease models. While this route is an easy to master, quick, …

Of all the molecules reported to have toxicological effects, BMAA (beta-methylamino alanine)
stands out as having the most checkered past. In the late 1960’s it was reported to be a …

Notch-1 (Notch) is a cell surface receptor that regulates cell-fate decisions in the developing
nervous system, and it may also have roles in synaptic plasticity in the adult brain. Binding …

The brain renin–angiotensin system continues to be enigmatic more than 40 years after the
brain was first recognized to be a site of action of angiotensin II. This review focuses on the …

Improvement of impaired neurological function(s) is a primary endpoint in experimental
stroke recovery studies, making the choice and nature of the functional tests crucial for proper …

Cerebral edema is a leading cause of mortality in stroke patients. The purpose of this study
was to assess a non-selective opioid receptor agonist, biphalin, in decreasing reducing brain …

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming …

In this study, we provide evidence for the first time that membrane‐bound endopeptidase
neurolysin is up‐regulated in different parts of mouse brain affected by focal ischemia‐…

Controlling angiotensin AT 1 receptor function has been shown to be protective for many
pathophysiological disorders. Although estrogen metabolite, 2-methoxyestradiol (2ME2) can …

Previous studies documented up‐regulation of peptidase neurolysin (Nln) after brain ischemia,
however, the significance of Nln function in the post‐stroke brain remained unknown. …