Since the discovery of the “nude” mouse more than 40 years ago, investigators have attempted
to model human tumor growth in immunodeficient mice. Here, we summarize how the …

The dysregulation of microRNA (miRNA) is implicated in cancer, inflammation, cardiovascular
disorders, drug resistance, and aging. While most researchers study miRNA’s role as a …

Immunodeficient mice engrafted with human HSCs support multidisciplinary translational
experimentation, including the study of human hematopoiesis. Heightened levels of human …

The inability to insert large DNA constructs into the genome efficiently and precisely is a key
challenge in genomic engineering. Random transgenesis, which is widely used, lacks …

The rhomboid 5 homolog 2 (Rhbdf2) gene encodes an inactive rhomboid (iRhom) protease,
iRhom2, one of a family of enzymes containing a long cytosolic N terminus and a dormant …

The development of mouse models of human disease and synthetic biology research by
targeted transgenesis of large DNA constructs represent a significant genetic engineering …

Multiple sites can be used for the engraftment of primary human cells and tissues into murine
hosts. For example, leukemias are usually best engrafted intravenously, but they can also …

Despite evidence that smoking confers protection against neurological disorders, how and
whether specific nicotinic receptor subtypes are involved is unknown. We reported previously …

Although researchers have yet to establish a link between muscular dystrophy (MD) and
sarcomas in human patients, literature suggests that the MD genes dystrophin and dysferlin act …

Background Gene disruption in mouse embryonic stem cells or zygotes is a conventional
genetics approach to identify gene function in vivo. However, because different gene disruption …