Cholesterol is essential for cell function and viability. It is a component of the plasma membrane
and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D. As a …

The estrogen-related receptors (ERRs) are important members of nuclear receptors which
contain three isoforms (α, β, and γ). ERRα is the best-characterized isoform expressed mainly …

Estrogens play a crucial role in the development of ovarian tumors; however, the signal
transduction pathways involved in hormone action are still poorly defined. The orphan G protein–…

The higher incidence of thyroid carcinoma (TC) in women during reproductive years compared
with men and the increased risk associated with the therapeutic use of estrogens have …

Leptin is a hormone with multiple biological actions, produced predominantly by adipose
tissue. In humans, plasma levels correlate with total body fat, and high concentrations occur in …

Human and animal models have evidenced how estrogen insufficiency is associated with
abnormal spermatogenesis and male infertility. We previously demonstrated that estradiol is …

Licorice root contains chemically diverse compounds that exhibit estrogenic effects in vitro
and in vivo. The chalcone isoliquiritigenin (ISL) is a component of licorice extract exhibiting …

Xenoestrogens are chemically distinct industrial products potentially able to disrupt the
endocrine system by mimicking the action of endogenous steroid hormones. Among such …

Inflammation represents an adaptive response generated by injuries or harmful stimuli.
Natural remedies represent an interesting alternative to traditional therapies, involving several …

The oncogenic KRAS mutation has a critical role in the initiation of human pancreatic ductal
adenocarcinoma (PDAC) since it rewires glutamine metabolism to increase reduced …