The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

SM Smith, WW Vale - Dialogues in clinical neuroscience, 2006 - Taylor & Francis
Animals respond to stress by activating a wide array of behavioral and physiological responses
that are collectively referred to as the stress response. Corticotropin-releasing factor (…

CRF and CRF receptors: role in stress responsivity and other behaviors

TL Bale, WW Vale - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI), …

The neurobiology of depression: inroads to treatment and new drug discovery

CB Nemeroff, WW Vale - Journal of Clinical Psychiatry, 2005 - psychiatrist.com
Vale has received grant/research support from the National Institutes of Health, Kleberg …
Bale TL, Vale WW. CRF and CRF receptors: role in stress responsivity and other behaviors. …

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

…, LW Swanson, PE Sawchenko, J Rivier, WW Vale… - Nature, 1983 - nature.com
Alternative processing of the RNA transcribed from the calcitonin gene appears to result in the
production of a messenger RNA in neural tissue distinct from that in thyroidal ‘C’ cells. The …

Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study

LW Swanson, PE Sawchenko, J Rivier, WW Vale - Neuroendocrinology, 1983 - karger.com
… Since antiserum 24 has been found to interн act with rat CRF particularly well in
radioimmunoassays [Vale, unн published observations], it was used extensively for the mapping …

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

…, J Rivier, PE Sawchenko, WW Vale - Proceedings of the …, 2001 - National Acad Sciences
The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian
peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine. The …

Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

…, J Gulyas, J Rivier, WW Vale… - Proceedings of the …, 2001 - National Acad Sciences
Here we describe the cloning and initial characterization of a previously unidentified CRF-related
neuropeptide, urocortin II (Ucn II). Searches of the public human genome database …

Expression cloning of a human corticotropin-releasing-factor receptor.

…, KA Lewis, MH Perrin, WW Vale - Proceedings of the …, 1993 - National Acad Sciences
Corticotropin-releasing factor (CRF) is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical
axis and plays an important role in coordinating the endocrine, autonomic…

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

…, LH Gold, PE Sawchenko, GF Koob, WW Vale… - Nature …, 2000 - nature.com
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal
(HPA) axis. In response to stress, Crh released from the paraventricular nucleus (…

Expression cloning of an activin receptor, a predicted transmembrane serine kinase

LS Mathews, WW Vale - Cell, 1991 - cell.com
Activins are involved in the regulation of multiple biological events, ranging from early
development to pituitary function. To characterize the cellular mechanisms involved in these …