A theoretical analysis has been made of the relationship between the inhibition constant (K I
) of a substance and the (I 50 ) value which expresses the concentration of inhibitor required …

3', 5'-Diamino-3', 5'-dideoxythymidine (7) was synthesized via a nine-step synthesis from
thymidine in good overall yield. 3'-Amino-3'-deoxythymidine (8) and 5'-amino-5'-…

The nucleoside analogue l-(2, 3-dideoxy-/3-Dg (ycero-pent-2-enofuranosyl) thymine (d4T, 1)
was prepared by ring opening of the 3', 5'-anhydro compound 5. This method has been …

We previously reported that the racemic mixture and both enantiomers of gossypol inhibit
the replication of human immunodeficiency virus-type 1 (HIV-1) (Lin et al., Antimicrob Agents …

Organoboron derivatives of pyrimidines and of 2,-deoxyribonucleosides have been
synthesized as potential antiviral and anticancer agents. Thefirst 5-boron-substituted pyrimidine …

The occasion of this 25th anniversary issue encouraged us to reminisce about the important
history of the discovery of the dideoxynucleoside analogues for the treatment of HIV/AIDS …

Various 3'-azido analogues of pyrimidine deoxyribonucleosides havebeen synthesized and
tested against human immunodeficiency virus (HIV-1, HTLV-III/LAV) in human peripheral …

Effects of chemical agents on viruses are discussed with regard to inhibition of virus adsorption,
inhibition of virus penetration and uncoating, and inhibition of an intracellular event. The …

Various 3'-azido, 3'-amino, 2', 3'-unsaturated, 2', 3'-dideoxy, and 5-substituted analogues of
pyrimidine deoxyribonucleosides have been prepared and tested against Moloney-murine …

Thymidine kinase derived from LMTK+ does not exhibit thymidylate kinase activity. However,
protein isolated by affinity column chromatography from thymidine kinase-deficient mouse …