[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
…, R Stoeber, Y Sugiyama, C Tetta, WE Thasler… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
…, T Volz, C Remouchamps, WM Chou, WE Thasler… - Science, 2014 - science.org
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
Interferon-γ and tumor necrosis factor-α produced by T cells reduce the HBV persistence form, cccDNA, without cytolysis
Background & Aims Viral clearance involves immune cell cytolysis of infected cells. However,
studies of hepatitis B virus (HBV) infection in chimpanzees have indicated that cytokines …
studies of hepatitis B virus (HBV) infection in chimpanzees have indicated that cytokines …
DNA methylation of lipid-related genes affects blood lipid levels
…, DG Hernandez, AB Singleton, WE Thasler… - Circulation …, 2015 - Am Heart Assoc
Background— Epigenetic mechanisms might be involved in the regulation of interindividual
lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this …
lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this …
A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
Background & Aims : Factors influencing the progression of chronic hepatitis C virus (HCV)
infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent …
infection are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent …
Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind …
…, C Schwarzmeier, B Renz, B Schreib, WE Thasler… - The Lancet, 2017 - thelancet.com
Background There is substantial uncertainty regarding the optimal surgical treatment for
chronic pancreatitis. Short-term outcomes have been found to be better after duodenum-…
chronic pancreatitis. Short-term outcomes have been found to be better after duodenum-…
Charitable state-controlled foundation human tissue and cell research: ethic and legal aspects in the supply of surgically removed human tissue for research in the …
WE Thasler, TS Weiss, K Schillhorn, PT Stoll… - Cell and tissue …, 2003 - Springer
Tissue engineering using human cells and tissue has one of the greatest scientific and
economical potential in the coming years. There are public concerns during the ongoing …
economical potential in the coming years. There are public concerns during the ongoing …
Toxicogenomics directory of chemically exposed human hepatocytes
…, MM Schaap, M Luijten, H Van Steeg, WE Thasler… - Archives of …, 2014 - Springer
A long-term goal of numerous research projects is to identify biomarkers for in vitro systems
predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for …
predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for …
Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases
…, K Frenes, KW Jauch, WE Thasler - Diseases of the Colon …, 2015 - journals.lww.com
BACKGROUND: Perioperative allogeneic red blood cell transfusion has been conclusively
shown to be associated with adverse oncologic outcomes after resection of nonmetastatic …
shown to be associated with adverse oncologic outcomes after resection of nonmetastatic …
Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth
…, H Winter, I Himsl, WE Thasler… - Proceedings of the …, 2017 - National Acad Sciences
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune
cells in several cancer models. We hypothesized that IL-22 regulation would occur at the …
cells in several cancer models. We hypothesized that IL-22 regulation would occur at the …