The 5‐HT1A and 5‐HT1B receptors of serotonin play important roles as auto‐ and heteroreceptors
controlling the release of serotonin itself and of other neurotransmitters/modulators in …

Substantial evidence indicates an association between clinical depression and altered
immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly …

All atypical antipsychotics avoid extrapyramidal side-effects yet differ in their propensity to
cause other side-effects, like prolactin elevation. We proposed that the atypical antipsychotics …

1‐[4‐(3‐piperidin‐1‐yl‐propoxy)‐benzyl]‐piperidine (JNJ‐5207852) is a novel, non‐imidazole
histamine H 3 receptor antagonist, with high affinity at the rat (pK i =8.9) and human (pK i …

Autoradiographic and membrane binding studies with[ 3H](R,S)-or[ 3 H](S)-zacopride were
performed in combination with lesions using various neurotoxins in an attempt to identify …

The cloning of novel G protein-coupled receptors and the search for their natural ligands, a
process called reverse pharmacology, is an excellent opportunity to discover novel …

We examined the pharmacological profile of (3,4-dihydro-2H-pyrano[2,3]b quinolin-7-yl) (cis-4-methoxycyclohexyl)
methanone (JNJ16259685). At recombinant rat and human …

The anatomical localization of 5‐HT 4 receptor mRNA and 5‐HT 4 receptor protein was
examined in sections of post‐mortem human brain by in situ hybridization histochemistry and …

Of all partners involved in G‐protein coupled receptor (GPCR) signalling, the regulator of G‐protein
signalling (RGS) proteins are the only ones showing fast gene expression changes …

… Specifically, a viability of at least 85% was measured for the polymeric formulations whereas
the cells incubated in presence of 1% Triton X-100 exhibited a viability of less than 15% (Fig…