The crystal structure of the DNA complex of a STAT-1 homodimer has been determined at
2.9 Å resolution. STAT-1 utilizes a DNA-binding domain with an immunoglobulin fold, similar …

Emerging evidence has linked the gut microbiome to human obesity. We performed a
metagenome-wide association study and serum metabolomics profiling in a cohort of lean and …

High rates of firm entry and exit have accompanied the rapid and sustained growth of output
in Taiwan's manufacturing sector. A high rate of firm turnover can contribute to industry …

Reports on bacteria detected in maternal fluids during pregnancy are typically associated
with adverse consequences, and whether the female reproductive tract harbours distinct …

Pyruvate kinase M2 (PKM2) is upregulated in multiple cancer types and contributes to the
Warburg effect by unclear mechanisms. Here we demonstrate that EGFR-activated ERK2 …

We report a family cluster of coronavirus disease 2019 (COVID-19) caused by a presymptomatic
case. There were 9 family members, including 8 laboratory-confirmed with COVID-19, …

BACKGROUND: Physicians in all fields of medicine may encounter patients with long QT
syndrome (LQTS). It is important to define the percentage of physicians capable of …

The crystal structure has been determined at 3.0 Å resolution for an unphosphorylated
STAT1 (1–683) complexed with a phosphopeptide derived from the α chain of interferon γ (IFNγ) …

FOXO1A and FOXO3A are two members of the FoxO family. FOXO3A has recently been
linked to human longevity in Japanese, German and Italian populations. Here we tested the …

Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these
proteins have been regarded as “undruggable.” We developed a decoy targeting STAT3 and …