Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …

Stress-responsive neurons of the hypothalamic paraventricular nucleus (PVN) show functional
plasticity and adapt to repeated restraint (RR) stress. To investigate whether neuronal …

Rho GTPases activated by GDP/GTP exchange factors (GEFs) play key roles in the
developing and adult nervous system. Kalirin-7 (Kal7), the predominant adult splice form of the …

Rats habituate to repeated exposure to homotypic stressors. The present studies were
designed to define how altered frequency of exposure to a stressor affects the development of …

Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the
underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived …

The hypothalamic-pituitary-adrenal axis adapts to periods of chronic or repeated stress. We
have now investigated whether there is any differential effect of repeated immobilization …

Major depressive disorder is the most prevalent psychiatric condition, but the cellular and
molecular mechanisms underlying this disorder are largely unknown, although multiple …

The structures of dendritic spines and the dendritic tree, key determinants of neuronal
function, are regulated by diverse inputs that affect many scaffolding and signaling molecules. …

Kalirin, a multifunctional Rho GDP/GTP exchange factor, plays a vital role in cytoskeletal
organization, affecting process initiation and outgrowth in neurons. Through alternative splicing, …

Alzheimer’s disease (AD) is characterized by the presence of neuritic plaques in which
dystrophic neurites (DNs) are typical constituents. We recently showed that DNs labeled by …