The 4-aryl-2-hydroxy-4-oxo-2-butenoic acids and their isosteric tetrazoles are among an
emerging class of aryl β-diketo (ADK)-based agents which exhibit potent inhibition of HIV-1 …

Long noncoding RNAs (lncRNAs) and promoter- or enhancer-associated unstable transcripts
locate preferentially to chromatin, where some regulate chromatin structure, transcription …

Among all the HIV-1 integrase inhibitors, the β-diketo acids (DKAs) represent a major lead
in anti-HIV-1 integrase drug design. These derivatives inhibit the integration reaction in vitro …

Background After the first monovalent 2009 pandemic influenza A (H1N1) vaccine became
available in September 2009, Chinese officials conducted a mass vaccination program in …

The β-diketo acids (DKAs) represent a major advance for anti–HIV-1 integrase drug development.
We compared the inhibition of HIV-1 integrase by six DKA derivatives using the wild-…

Ice, Cloud, and Land Elevation Satellite-2 (ICESat-2) has shown great potential for near-shore
bathymetry. Unavoidably, the photon data acquired has a lot of noise. In order to remove …

We previously found that azido-containing β-diketo acid derivatives (DKAs) are potent inhibitors
of human immunodeficiency virus type 1 (HIV-1) integrase (IN) (X. Zhang et al., Bioorg. …

The key areas of China's urbanization process have gradually shifted from urban areas to
county-level units. Correspondingly, air pollution in county towns may be heavier than in urban …

The ceramic core plays an important role in the preparation of aero-engine hollow blades,
as it can directly determine the precision and pass rate of the cooling passage in the blade …

In this work, two different functionalized graphene oxide (GO), sulfonic acid functionalized
GO (SGO) and amino functionalized GO (NGO), were synthesized and incorporated into the …