Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT3A, TPMT2): Mechanisms for the genetic …

…, EG Schuetz, Y Yanishevski… - Proceedings of the …, 1997 - National Acad Sciences
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic
sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT …

Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation

…, JD Schuetz, Y Yanishevski… - Blood, The Journal …, 1999 - ashpublications.org
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of
acute lymphoblastic leukemia (ALL). To elucidate the mechanism for higher accumulation of …

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

MV Relling, Y Yanishevski, J Nemec, WE Evans… - Leukemia, 1998 - nature.com
Etoposide, an effective agent for acute lymphoblastic leukemia (ALL), can cause secondary
acute myeloid leukemia (AML) in a subset of patients. Our objectives were to determine …

Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for …

AJ Galpin, JD Schuetz, E Masson, Y Yanishevski… - Molecular …, 1997 - ASPET
Cellular accumulation of methotrexate polyglutamates (MTXPGs) is recognized as an
important determinant of the cytotoxicity and selectivity of methotrexate in acute lymphoblastic …

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.

EY Krynetski, NF Krynetskaia, Y Yanishevski… - Molecular …, 1995 - ASPET
Thiopurine S-methyltransferase (TPMT), a cytosolic enzyme that exhibits genetic polymorphism,
catalyzes S-methylation of mercaptopurine (MP) and thioguanine (TG), yielding S-…

In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.

FM Uckun, RK Narla, T Zeren, Y Yanishevski… - Clinical cancer research …, 1998 - AACR
Epidermal growth factor receptor (EGFR)-associated protein tyrosine kinase (PTK)
complexes have vital anti-apoptotic functions in human breast cancer cells. We have shown …

A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia

J Panetta, Y Yanishevski, CH Pui, JT Sandlund… - Cancer chemotherapy …, 2002 - Springer
Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute
lymphoblastic leukemia (ALL). Interindividual differences in lymphoblast accumulation of …

In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin.

…, EA Schneider, N Tumer, Y Yanishevski… - Clinical cancer research …, 1997 - AACR
We evaluated the TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunotoxin in both
murine and nonhuman primate models. TXU-PAP caused dose-limiting cardiac toxicity in BALB/…

Pharmacokinetic features, immunogenicity, and toxicity of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin in cynomolgus monkeys.

FM Uckun, Y Yanishevski, N Tumer… - Clinical cancer research …, 1997 - AACR
We studied the pharmacokinetic features, immunogenicity, and toxicity of B43-pokeweed
antiviral protein (PAP) immunotoxin in 13 cynomolgus monkeys. The disposition of B43-PAP in …

Prevalence and growth characteristics of malignant stem cells in B-lineage acute lymphoblastic leukemia

…, E Coustan-Smith, Y Yanishevski… - Blood, The Journal …, 1997 - ashpublications.org
We used a stroma-supported culture method to study the prevalence and growth
characteristics of malignant stem cells in acute lymphoblastic leukemia (ALL). In 51 of 108 B-lineage …