Nrf2 in cancers: A double‐edged sword

S Wu, H Lu, Y Bai - Cancer medicine, 2019 - Wiley Online Library
The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of
oxidative damage induced by exogenous chemicals. It maintains the redox homeostasis, …

[HTML][HTML] Molecular mechanism of pancreatic stellate cells activation in chronic pancreatitis and pancreatic cancer

G Jin, W Hong, Y Guo, Y Bai, B Chen - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of fibrosis,
a major pathological feature in pancreatic diseases that including chronic pancreatitis and …

An overview of hedgehog signaling in fibrosis

L Hu, X Lin, H Lu, B Chen, Y Bai - Molecular pharmacology, 2015 - ASPET
The Hedgehog (Hh) signaling pathway plays a key role during embryogenesis and tissue
regeneration. Recently, studies revealed that overactivated Hh signaling leads to fibrogenesis …

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

…, Q Ruan, X Zhang, W Hong, S Wu, G Jin, Y Bai - Biochemical …, 2018 - Elsevier
Interstitial inflammation is the main pathological feature in kidneys following injury, and the
polarization of macrophages is involved in the process of inflammatory injury. Previous …

Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways

…, H Guo, L Shang, W Zheng, S Ma, X Liu, Y Bai - Cell Biology and …, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDA) is an aggressive type of malignant tumor with a
poor prognosis and high mortality. Aberrant activation of hedgehog signaling plays a crucial …

Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling

…, S Xie, H Jiang, S Sun, R Lin, C Chen, Y Bai… - International …, 2021 - Elsevier
Sodium glucose cotransporter-2 (SGLT-2) inhibitor has been reported to exert a glucose-lowering
effect in the peritoneum exposed to peritoneal dialysis solution. However, whether …

[HTML][HTML] Hedgehog signaling in pancreatic fibrosis and cancer

Y Bai, Y Bai, J Dong, Q Li, Y Jin, B Chen, M Zhou - Medicine, 2016 - journals.lww.com
… Yongyu Bai and Yongheng Bai contributed equally to this work. Study concept and design:
Yongyu Bai, Yongheng Bai, MZ. Drafting of the manuscript: Yongyu Bai, Yongheng Bai, JD, …

Resveratrol inhibits epithelial-mesenchymal transition and renal fibrosis by antagonizing the hedgehog signaling pathway

Y Bai, H Lu, C Wu, Y Liang, S Wang, C Lin… - Biochemical …, 2014 - Elsevier
Epithelial-to-mesenchymal transition (EMT), a biologic process in which tubular cells lose
their epithelial phenotypes and acquire new characteristic features of mesenchymal properties…

[HTML][HTML] Inhibition of STAT3Y705 phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells

…, M Wang, L Xie, Q Chen, Y Tong, Q Zhang, Y Bai - Cell Death …, 2022 - nature.com
Patients with pancreatic cancer (PC) show dismal prognosis and high mortality. The development
of PC is associated with the overactivation of STAT3. Here, we have determined that …

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2–IRF pathway

J Yuan, F Lin, L Chen, W Chen, X Pan, Y Bai… - …, 2022 - Springer
Lipoxin A4 (LXA4) has been shown to have anti-inflammatory activity, but its underlying
molecular mechanisms are not clear. Herein, we investigated the potential role of LXA4 in …