BACKGROUND & AIMS: Acute pancreatitis is characterized by early activation of
intracellular proteases followed by acinar cell death and inflammation. Activation of damage-…

There is very limited human renal sodium gradient-dependent glucose transporter protein (SGLT2)
mRNA and protein expression data reported in the literature. The first aim of this …

Obesity and diabetes mellitus are the leading causes of renal disease. In this study, we
determined the regulation and role of the G protein-coupled bile acid receptor TGR5, previously …

Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the
G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective …

Obesity and obesity related kidney and liver disease have become more prevalent over the
past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) …

Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A
proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes …

Even in healthy individuals, renal function gradually declines during aging. However, an
observed variation in the rate of this decline has raised the possibility of slowing or delaying age…

Automated extraction of roads from remotely sensed data come forth various usages ranging
from digital twins for smart cities, intelligent transportation, urban planning, autonomous …

The farnesoid X receptor (FXR) belongs to a family of ligand-activated transcription factors
that regulate many aspects of metabolism including bile acid homeostasis. Here we show that …

Nonalcoholic fatty liver disease (NAFLD) is widespread in adults and children. Early exposure
to maternal obesity or Western-style diet (WD) increases steatosis and oxidative stress in …